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  3. EPDR1 蛋白, Human (HEK293, His)

EPDR1 蛋白, Human (HEK293, His)

目录号: HY-P70935
产品使用指南

在大鼠模型中,EPDR1 蛋白通过结合并激活 TIE2 受体,启动其酪氨酸磷酸化,发挥关键的调节作用。这种相互作用影响内皮发育过程,与 VEGF 的作用不同,VEGF 介导内皮与周围基质和间质之间的相互作用。EPDR1 蛋白, Human (HEK293, His) 是重组的 EPDR1 蛋白,由 HEK293 表达,带有 C-6*His 标签。

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描述

In the rat model, the EPDR1 protein plays a key regulator role by binding to and activating the TIE2 receptor, initiating its tyrosine phosphorylation. This interaction affects processes of endothelial development that are distinct from the effects of VEGF, which mediates interactions between the endothelium and the surrounding matrix and interstitium. EPDR1 Protein, Human (HEK293, His) is the recombinant human-derived EPDR1 protein, expressed by HEK293 , with C-6*His labeled tag.

研究背景

ANGPT1,特别是在大鼠模型中,通过结合并激活 TIE2 受体充当关键调节因子,从而启动其酪氨酸磷酸化。这种分子相互作用涉及内皮发育过程,与 VEGF 的影响不同,并且在内皮与周围基质和间质之间的相互作用中发挥着至关重要的作用。ANGPT1 的参与延伸到介导血管成熟和稳定性,表明其在血管发育中的重要性。此外,越来越多的证据表明它在心脏早期发育中具有潜在的重要性。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q9UM22-1 (A38-S223)

基因 ID
蛋白结构
N-term
EPDR1 (A38-S223)
Accession # Q9UM22-1
6*His
C-term
同用名
Mammalian ependymin-related protein 1; EPDR1; Upregulated in colorectal cancer gene 1 protein; MERP1
氨基酸序列

APRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCS

分子量

28 &33 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

EPDR1 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
EPDR1 Protein, Human (HEK293, His)
目录号:
HY-P70935
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