Coagulation Factor XII/F12 蛋白, Pig (P. pastoris, His)

Coagulation factor XII (F12) is a serum glycoprotein that plays multiple roles in initiating blood coagulation, fibrinolysis, and the production of bradykinin and angiotensin. It is involved in these complex processes, including cleavage of prekallikrein to form kallikrein, which subsequently cleaves factor XII initially to α-factor XIIa and then, after trypsin cleavage, to β-factor XIIa. Coagulation Factor XII/F12 Protein, Pig (P. pastoris, His) is the recombinant pig-derived F12/Coagulation Factor XII, Pig, expressed by P. pastoris , with N-6*His labeled tag.

凝血因子 XII，也称为 F12，是一种血清糖蛋白，在启动血液凝固、纤维蛋白溶解以及缓激肽和血管紧张素的生成中具有多方面的作用。XII 因子通过裂解前激肽释放酶形成激肽释放酶，参与复杂的级联事件。随后，因子 XII 自身进行裂解，首先裂解为 α-因子 XIIa，然后通过胰蛋白酶活性裂解为 β-因子 XIIa。值得注意的是，α-因子 XIIa 参与因子 XI 向因子 XIa 的激活，有助于凝血级联的传播。

Pig

P. pastoris

N-6*His

O97507 (I20-R371)

397474  [NCBI]

IPPWKDPRKHKVMASEHTVVLTVTGEPCHFPFQYYRQLYYKCIQRGQRGPRPWCATTPNFEKDQRWAYCLEPMKVKDHCNKGNPCQKGGTCVNMPNGPHCICPDHFTGKHCQKEKCFEPQFLQFFQENEIWHRFEPAGVSKCQCKGPKAQCKPVASQVCSTNPCLNGGSCLQTEGHRLCRCPTGYAGRLCDVDLKERCYSDRGLSYRGMAQTTLSGAPCQPWASEATYWNMTAEQALNWGLGDHAFCRNPDNDTRPWCFVWRGDQLSWQYCRLARCQAPIGEAPPILTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNR

41.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.