Fibulin-3 蛋白, Mouse (HEK293, His)

Fibulin-3 protein plays multiple roles, binding to EGFR to induce downstream signaling and affecting cell adhesion and migration. It may negatively regulate chondrocyte differentiation and affect glial cell function in the olfactory epithelium, including migration, differentiation, and support of neurite outgrowth. Fibulin-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Fibulin-3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Fibulin-3 Protein, Mouse (HEK293, His) is 476 a.a., with molecular weight of 60-80 kDa.

Fibulin-3 蛋白通过与 EGFR（EGF 受体）结合，导致 EGFR 自磷酸化并随后激活下游信号通路，从而发挥多方面的作用。这种相互作用表明它参与关键的细胞过程，例如细胞粘附和迁移。此外，Fibulin-3 可能充当软骨细胞分化的负调节因子，并且在嗅觉上皮中，可能调节神经胶质细胞迁移、分化以及神经胶质细胞支持神经元轴突生长的能力。此外，它与 ECM1 和 TIMP3 相互作用，表明它参与了有助于各种细胞功能的复杂分子网络。

Mouse

HEK293

N-His

Q8BPB5 (Q18-F493)

216616  [NCBI]

QYTEETITYTQCTDGYEWDPIRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEHPQQETPAAEASSGATTGTVAARSMATSGVVPGGGFMASATAVAGPEVQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTSGTHNCRTDQVCINLRGSFTCQCLPGYQKRGEQCVDIDECTVPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYEVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDHYVLTSENRCVCPVSNTMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATMIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREYIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF

60-80 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.