Galectin-3/LGALS3 蛋白, Mouse

Galectin-3 (LGALS3) is involved in multiple activities, including IgE binding and signaling receptor binding. It negatively regulates T-cell receptor signaling and modulates immune responses by modulating endocytosis and lymphocyte activation. Galectin-3/LGALS3 Protein, Mouse is the recombinant mouse-derived Galectin-3/LGALS3 protein, expressed by E. coli , with tag free.

Galectin-3 (LGALS3) 是一种多功能蛋白，预计可参与多种活性，包括 IgE 结合、高级糖基化终产物受体活性和信号受体结合。它参与 T 细胞受体信号通路、内吞作用和淋巴细胞激活的负调节，强调了它在调节免疫反应中的关键作用。Galectin-3 位于各种细胞成分中，包括质膜外侧、神经胶质细胞投射和免疫突触，在细胞外基质组织和骨骼系统发育等过程的上游发挥作用。Galectin-3 广泛表达于消化系统、泌尿生殖系统、呼吸系统、骨骼和皮肤等解剖结构中，在多种生理环境中具有重要意义。值得注意的是，它在特定组织（例如结肠和十二指肠）中表现出偏向表达，表明在这些解剖区域中具有特殊作用。对这种蛋白质的研究可能有助于了解其对哮喘和脂肪肝等疾病的影响。

Measured by the ability of the immobilized protein to support the adhesion of CTLL-2 cells. The ED₅₀ for this effect is 1.370 μg/mL, corresponding to a specific activity is 729.927 units/mg.

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  Measured by the ability of the immobilized protein to support the adhesion of CTLL-2 cells. The ED₅₀ for this effect is 1.370 μg/mL, corresponding to a specific activity is 729.927 units/mg.

Mouse

E. coli

Tag Free

NP_034835.1 (A2-I264)

16854  [NCBI]

ADSFSLNDALAGSGNPNPQGYPGAWGNQPGAGGYPGAAYPGAYPGQAPPGAYPGQAPPGAYPGQAPPSAYPGPTAPGAYPGPTAPGAYPGSTAPGAFPGQPGAPGAYPSAPGGYPAAGPYGVPAGPLTVPYDLPLPGGVMPRMLITIMGTVKPNANRIVLDFRRGNDVAFHFNPRFNENNRRVIVCNTKQDNNWGKEERQSAFPFESGKPFKIQVLVEADHFKVAVNDAHLLQYNHRMKNLREISQLGISGDITLTSANHAM

Approximately 30 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.