2. Gene
  3. Lgals3 - lectin, galactose binding, soluble 3 Gene

Lgals3 - lectin, galactose binding, soluble 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GBP; L-34; gal3; Mac-2

基因 ID: 16854 | 基因类型: protein coding

关于 Lgals3

功能概要

Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (Galectin 3). [provided by Alliance of Genome Resources, Apr 2022]

Lgals3 基因产物(2)

mRNA Protein Name
NM_001145953.1 NP_001139425.1 galectin-3
NM_010705.3 NP_034835.1 galectin-3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10745073 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within extracellular matrix organization IGI
IGI: 通过遗传相互作用推断
15800063 MGI
NOT involved in maintenance of protein location IDA
IDA: 通过直接分析推断
21670307 MGI
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
IMP: 通过突变表型推断
19706535 MGI
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
19706535 MGI
involved in negative regulation of endocytosis IMP
IMP: 通过突变表型推断
19706535 MGI
involved in negative regulation of immunological synapse formation IMP
IMP: 通过突变表型推断
19706535 MGI
acts upstream of or within skeletal system development IGI
IGI: 通过遗传相互作用推断
15800063 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
23576987 MGI
is active in cornified envelope IDA
IDA: 通过直接分析推断
26644517 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10745073 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
23460747 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
15800063 MGI
located in glial cell projection IDA
IDA: 通过直接分析推断
20826656 MGI
located in immunological synapse IDA
IDA: 通过直接分析推断
19706535 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10745073 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

galectin-3

35 kDa lectin

CBP 35

L-34 galactoside-binding lectin

carbohydrate-binding protein 35

gal-3

galactose-specific lectin 3

igE-binding protein

laminin-binding protein

lectin L-29

mac-2 antigen

重组 Lgals3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77684 Galectin-3/LGALS3 Protein, Mouse (HEK293, His) P16110 (A2-I264) ≥95%
HY-P79079 Galectin-3/LGALS3 Protein, Mouse NP_034835.1 (A2-I264) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07604 LGALS3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07605 LGALS3BP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lgals3 NCBI NCBI:3958
Macaca fascicularis Lgals3 NCBI NCBI:102145569
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