GARP&Latent TGF beta Complex 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

GARP/latent TGF-b1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein (GARP (I18-N628)&TGF-b1 (L30-S390)) produced by HEK293 cells with His-Avi tag^[1][2].

GARP/潜在 TGF-b1 复合物在外源性 IL-6 存在的情况下是 Th17 分化的有效诱导剂，在 IL-2 存在的情况下是 Treg 的诱导剂^{[1][2].
GARP/LTGFβ1 复合物在新鲜移植的 Treg 上表达水平非常低，但在体外 Treg 激活后显着上调。GARP/Treg 细胞上的潜在 TGF-β1 复合物在口服耐受期间调节外周衍生 Treg 细胞的诱导[3]}

Mouse

HEK293

N-His;N-Avi

G3XA59 (I18-N628)&P04202 (L30-S390)

434215  [NCBI]&21803  [NCBI]

72-76 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Soyoung A Oh,TGF-β: guardian of T cell function. J Immunol. 2013 Oct 15;191(8):3973-9.  [Content Brief]

  [2]. Angela X Zhou, et al. GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol. 2013 May 15;190(10):5057-64.  [Content Brief]

  [3]. Justin P Edwards, et al. The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance. Eur J Immunol. 2016 Jun;46(6):1480-9.  [Content Brief]