1. Gene
  2. Tgfb1 - transforming growth factor, beta 1 Gene

Tgfb1 - transforming growth factor, beta 1 Gene

中文名称:转化生长因子, β 1

种属: Mus musculus

同用名: Tgfb; Tgfb-1; TGFbeta1; TGF-beta1

基因 ID: 21803 | 基因类型: protein coding

关于 Tgfb1

Chromosome 7: 25,386,427-25,404,502 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 210 orthologues, 32 paralogues and is associated with 137 phenotypes. Broad expression in spleen adult (RPKM 74.6), thymus adult (RPKM 41.1) and 19 other tissues.

功能概要

该基因编码 TGF-β(转化生长因子-β)蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体,导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理以生成潜伏相关肽 (LAP) 和成熟肽,并且以由成熟肽同二聚体、LAP 同二聚体和潜伏 TGF-β 结合蛋白组成的潜伏形式被发现,或者以仅由成熟肽同源二聚体组成的活性形式存在。成熟肽还可以与其他 TGF-β 家族成员形成异二聚体。这种编码的蛋白质调节细胞增殖、分化和生长,并可以调节其他生长因子的表达和激活,包括干扰素 γ 和肿瘤坏死因子 α。缺乏该基因功能拷贝的小鼠会发展为严重的多灶性炎症性疾病、卵黄囊缺陷和结肠癌。 [RefSeq 提供,2016 年 8 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of Other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon Cancer. [provided by RefSeq, Aug 2016]

Tgfb1 基因产物(2)

mRNA Protein Name
NM_011577.2 NP_035707.1 transforming growth factor beta-1 proprotein preproprotein
NM_011577.2 NP_035707.1 transforming growth factor beta-1 proprotein preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12773577 MGI
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
25065622 MGI
enables transforming growth factor beta receptor binding IPI
IPI: 通过物理相互作用推断
17878231 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Langerhans cell differentiation IMP
IMP: 通过突变表型推断
17938236 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
25446530 MGI
acts upstream of or within T cell activation IDA
IDA: 通过直接分析推断
18997793 MGI
acts upstream of T cell activation IMP
IMP: 通过突变表型推断
12646629 MGI
acts upstream of or within T cell activation IMP
IMP: 通过突变表型推断
17481928 MGI
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
17481928 MGI
acts upstream of or within T cell homeostasis IMP
IMP: 通过突变表型推断
17481928 MGI
acts upstream of T cell proliferation IMP
IMP: 通过突变表型推断
17481928 MGI
involved in adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IDA
IDA: 通过直接分析推断
19501566 MGI
involved in aortic valve morphogenesis IMP
IMP: 通过突变表型推断
26634652 MGI
acts upstream of or within branch elongation involved in mammary gland duct branching IMP
IMP: 通过突变表型推断
18614704 MGI
acts upstream of or within bronchiole development IDA
IDA: 通过直接分析推断
12634787 MGI
acts upstream of or within bronchiole development IMP
IMP: 通过突变表型推断
12634787 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
29715368 MGI
acts upstream of or within cell activation IDA
IDA: 通过直接分析推断
21956870 MGI
acts upstream of or within cell morphogenesis IDA
IDA: 通过直接分析推断
17641300 MGI
acts upstream of cell population proliferation IDA
IDA: 通过直接分析推断
15604101 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of or within cellular response to ionizing radiation IMP
IMP: 通过突变表型推断
17916808 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IDA
IDA: 通过直接分析推断
23861879 MGI
involved in cellular response to virus IDA
IDA: 通过直接分析推断
18802055 MGI
acts upstream of or within columnar/cuboidal epithelial cell maturation IMP
IMP: 通过突变表型推断
31336344 MGI
acts upstream of or within connective tissue development IGI
IGI: 通过遗传相互作用推断
25715398 MGI
involved in embryonic liver development IMP
IMP: 通过突变表型推断
7600998 MGI
acts upstream of or within endoderm development IDA
IDA: 通过直接分析推断
9921650 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: 通过直接分析推断
12208849 MGI
involved in extracellular matrix assembly IDA
IDA: 通过直接分析推断
19734317 MGI
involved in face morphogenesis IEP
IEP: 通过表达模式推断
18498113 MGI
acts upstream of or within gene expression IDA
IDA: 通过直接分析推断
29715368 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
18802055 MGI
acts upstream of or within germ cell migration IDA
IDA: 通过直接分析推断
15993878 MGI
involved in heart development IMP
IMP: 通过突变表型推断
7600998 MGI
involved in heart valve morphogenesis IMP
IMP: 通过突变表型推断
8009224 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
1436033 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: 通过突变表型推断
12646629 MGI
acts upstream of or within lens fiber cell differentiation IMP
IMP: 通过突变表型推断
17215516 MGI
acts upstream of or within lung alveolus development IDA
IDA: 通过直接分析推断
12634787 MGI
acts upstream of or within lymph node development IMP
IMP: 通过突变表型推断
1436033 MGI
acts upstream of or within mammary gland branching involved in thelarche IMP
IMP: 通过突变表型推断
18614704 MGI
acts upstream of or within mammary gland development IDA
IDA: 通过直接分析推断
1821856 MGI
acts upstream of or within mononuclear cell proliferation IMP
IMP: 通过突变表型推断
17481928 MGI
acts upstream of or within muscle cell cellular homeostasis IGI
IGI: 通过遗传相互作用推断
25715398 MGI
acts upstream of or within negative regulation of T cell activation IMP
IMP: 通过突变表型推断
12646629 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
17481928 MGI
involved in negative regulation of biomineral tissue development IMP
IMP: 通过突变表型推断
26634652 MGI
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
12773577 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
26634652 MGI
involved in negative regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
18368049 MGI
acts upstream of or within negative regulation of ossification IDA
IDA: 通过直接分析推断
15820682 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15657445 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15990875 MGI
involved in neural tube closure IMP
IMP: 通过突变表型推断
7600998 MGI
involved in neural tube development IMP
IMP: 通过突变表型推断
7600998 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: 通过直接分析推断
29715368 MGI
involved in odontoblast differentiation IMP
IMP: 通过突变表型推断
33548622 MGI
involved in oligodendrocyte development IMP
IMP: 通过突变表型推断
22384214 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: 通过直接分析推断
21841309 MGI
acts upstream of or within osteoclast differentiation IGI
IGI: 通过遗传相互作用推断
21841309 MGI
acts upstream of or within phospholipid homeostasis IDA
IDA: 通过直接分析推断
17641300 MGI
acts upstream of or within phospholipid homeostasis IMP
IMP: 通过突变表型推断
17641300 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15100250 MGI
involved in positive regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
12773577 MGI
involved in positive regulation of collagen biosynthetic process IDA
IDA: 通过直接分析推断
19734317 MGI
acts upstream of or within positive regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
18794329 MGI
acts upstream of positive regulation of extracellular matrix assembly IDA
IDA: 通过直接分析推断
24279830 MGI
acts upstream of or within positive regulation of fibroblast migration IMP
IMP: 通过突变表型推断
23871832 MGI
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
23871832 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
17293613 MGI
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
21984612 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
26634652 MGI
involved in positive regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
19501566 MGI
involved in positive regulation of microglia differentiation IMP
IMP: 通过突变表型推断
29909984 MGI
acts upstream of or within positive regulation of odontogenesis IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of or within positive regulation of protein localization to nucleus IGI
IGI: 通过遗传相互作用推断
21911934 MGI
involved in positive regulation of regulatory T cell differentiation IMP
IMP: 通过突变表型推断
25065622 MGI
acts upstream of or within positive regulation of stem cell proliferation IDA
IDA: 通过直接分析推断
15604101 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15990875 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17568773 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
31336344 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
12208849 MGI
acts upstream of or within protein phosphorylation IGI
IGI: 通过遗传相互作用推断
17898001 MGI
acts upstream of or within regulation of DNA binding IDA
IDA: 通过直接分析推断
15282343 MGI
acts upstream of or within regulation of actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
21911934 MGI
acts upstream of or within regulation of binding IDA
IDA: 通过直接分析推断
15282343 MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis IGI
IGI: 通过遗传相互作用推断
17898001 MGI
acts upstream of or within regulation of cartilage development IDA
IDA: 通过直接分析推断
20501701 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
19056892 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11799106 MGI
acts upstream of regulation of enamel mineralization IMP
IMP: 通过突变表型推断
30243146 MGI
NOT involved in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
19161227 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
23871832 MGI
involved in regulation of interleukin-23 production IDA
IDA: 通过直接分析推断
18368049 MGI
acts upstream of or within regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
11799106 MGI
acts upstream of or within regulation of regulatory T cell differentiation IGI
IGI: 通过遗传相互作用推断
21245484 MGI
acts upstream of or within regulation of sodium ion transport IDA
IDA: 通过直接分析推断
16941024 MGI
acts upstream of or within regulation of striated muscle tissue development IDA
IDA: 通过直接分析推断
11711431 MGI
acts upstream of or within regulatory T cell differentiation IDA
IDA: 通过直接分析推断
15100250 MGI
acts upstream of or within regulatory T cell differentiation IMP
IMP: 通过突变表型推断
17481928 MGI
acts upstream of or within retina vasculature development in camera-type eye IDA
IDA: 通过直接分析推断
29715368 MGI
acts upstream of stem cell proliferation IDA
IDA: 通过直接分析推断
15604101 MGI
acts upstream of or within surfactant homeostasis IDA
IDA: 通过直接分析推断
17641300 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: 通过突变表型推断
17641300 MGI
acts upstream of or within tolerance induction to self antigen IMP
IMP: 通过突变表型推断
17481928 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
12208849 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
12773577 MGI
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
8009224 MGI
involved in ureteric bud development IEP
IEP: 通过表达模式推断
14656760 MGI
involved in vasculogenesis IMP
IMP: 通过突变表型推断
7600998 MGI
involved in ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
8009224 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
31336344 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
2209468 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
18753609 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Tgfb1 蛋白结构

TGFb_propeptide

TGFb_propeptide: pfam00688 (29 - 260)

TGF_beta_TGFB1

TGF_beta_TGFB1: cd19384 (291 - 389)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

transforming growth factor beta-1 proprotein

transforming growth factor beta-1 proprotein

重组 Tgfb1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7117 TGF beta 1/TGFB1 Protein, Rat/Mouse (HEK293) P04202/P17246 (A279-S390) ≥95%
HY-P70648 TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293) P04202(A279-S390) ≥95%
HY-P77677 GARP&Latent TGF beta Complex Protein, Mouse (HEK293, His) G3XA59 (A18-L628)&P04202 (L30-S390) ≥95%
HY-P77678 GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi) G3XA59 (I18-N628)&P04202 (L30-S390) ≥95%
HY-P78360 Latent TGF beta 1/TGFB1 Protein, Mouse (HEK293, His) P04202 (L30-S390) ≥95%
HY-P700227AF Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His) P04202 (A279-S390) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tgfb1 NCBI NCBI:7040
Canis familiaris Tgfb1 NCBI NCBI:403998
Macaca fascicularis Tgfb1 NCBI NCBI:102129546
Susscrofa domestica Tgfb1 NCBI
Rattus norvegicus Tgfb1 NCBI NCBI:59086
Macaca mulatta Tgfb1 NCBI NCBI:106992315