Tgfb1 - transforming growth factor, beta 1 Gene

中文名称：转化生长因子， β 1

种属: Rattus norvegicus

同用名: Tgfb

关于 Tgfb1

功能概要

实现相同的蛋白质结合活性和蛋白质 N 末端结合活性。参与多个过程，包括动物器官发育；细胞对激素刺激的反应；和调节上皮细胞增殖。在平滑肌细胞分化的正调节上游或正调节内起作用。位于多个细胞成分中，包括细胞表面；神经细胞体；和分泌颗粒。用于研究慢性阻塞性肺疾病；家族性高脂血症；高血压;蛋白尿;和肺纤维化。多种疾病的生物标志物，包括过敏性鼻炎；动脉疾病（多发性）；脑血管疾病（多发）；胃肠系统癌症（多发性）；和肺部疾病（多种）。该基因的人类直系同源基因与多种疾病有关，包括白塞病； Camurati-Engelmann 病；口疮性口炎;动脉疾病（多发性）；和肺部疾病（多种）。与人 TGFB1（转化生长因子 β 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system Cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1). [provided by Alliance of Genome Resources, Apr 2022]