GAS6 蛋白, Human (HEK293, C-His)

The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes.GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses.GAS6 Protein, Human (HEK293, C-His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-6*His labeled tag.

GAS6 是酪氨酸蛋白激酶受体 AXL、TYRO3 和 MER 的配体，参与多种细胞过程，包括细胞生长、存活、粘附和迁移。GAS6/AXL 信号传导通过防止细胞凋亡，有助于酸性条件下内皮细胞的存活，促进人类自然杀伤细胞发育过程中的最佳细胞因子信号传导，在肝再生中发挥作用，影响促性腺激素释放激素神经元的存活和迁移，调节血小板活化，并调节血栓反应。此外，在微生物感染中，GAS6 可以充当病毒包膜磷脂酰丝氨酸和 TAM 受体酪氨酸激酶 Axl 之间的桥梁，通过凋亡拟态促进病毒进入。这种独特的功能延伸到它参与多种病毒的进入过程，包括登革热、痘苗病毒、埃博拉病毒和马尔堡病毒，突显了 GAS6 在细胞和感染环境中的多方面作用。

Measured by its ability to down regulate the expression of Axl in DU145 human prostate carcinoma cells. The ED₅₀ for this effect is 15-50 ng/mL.

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  Measured by its ability to down regulate the expression of Axl in DU145 human prostate carcinoma cells. The ED₅₀ for this effect is 27.66 ng/mL. Corresponding to a specific activity is 3.6×10⁴ U/mg.

Human

HEK293

C-6*His

Q14393-2 (A31-A678)

2621

ALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA

Approximately 75-95 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.