2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family
  6. GFR-alpha-3
  7. GFRA3/GDNFR-alpha-3 蛋白, Mouse (HEK293, His)

GFRA3/GDNFR-alpha-3 蛋白, Mouse (HEK293, His)

目录号: HY-P76952
产品使用指南

GFRA3/GDNFR-α-3 蛋白是神经胶质细胞系源性神经营养因子 (artemin) 的受体，可促进 artemin 诱导的自身磷酸化和 RET 受体酪氨酸激酶激活。它与 SORL1 相互作用，暗示可能参与与神经营养反应相关的信号级联反应。GFRA3/GDNFR-alpha-3 蛋白, Mouse (HEK293, His) 是重组的 GFRA3/GDNFR-alpha-3 蛋白，由 HEK293 表达，带有 C-His 标签。

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描述

GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag.
研究背景

GFRA3/GDNFR-α-3 蛋白作为神经胶质细胞系衍生的神经营养因子 artemin 的受体，促进 artemin 诱导的自身磷酸化和 RET 受体酪氨酸激酶的激活。该蛋白与 SORL1 相互作用，表明可能参与与神经营养反应相关的信号级联反应。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

O35118 (N29-R379)
基因 ID
蛋白结构
N-term
GFRA3/GDNFR-alpha-3 (N29-R379)
Accession # O35118
His
C-term
同用名
GDNF family receptor alpha-3; GFR-alpha-3
分子量

42-52 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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