GFRAL 蛋白, Mouse (HEK293, His-Avi)

GFRAL protein, a brainstem-restricted receptor, regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. It binds with GDF15, interacts with RET, and activates MAPK- and AKT- signaling pathways. GFRAL acts as a receptor for GDF15 and mediates cellular signaling through RET, requiring prior GDF15 binding. GFRAL Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived GFRAL protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

GFRAL 蛋白是一种脑干限制性受体，在调节食物摄入、能量消耗和体重以应对代谢和毒素引起的压力方面发挥着至关重要的作用。在与其配体 GDF15 结合后，GFRAL 与 RET 相互作用并激活 MAPK 和 AKT 信号传导通路。GFRAL 通过其胞外结构域与 GDF15 和 RET 相互作用，充当 GDF15 的受体，并在 GDF15 结合后通过与 RET 的相互作用介导细胞信号传导。值得注意的是，与 RET 的相互作用需要先前的 GDF15 结合。

Immobilized Mouse GFRAL, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Mouse GDF15, hFc Tag with the EC₅₀ of less than 6.5ng/ml determined by ELISA.

Mouse

HEK293

N-His;N-Avi

Q6SJE0-1 (Q20-E350)

404194  [NCBI]

48-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS (pH 7.4).Normally 8% Trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.