2. Gene
  3. Gfral - GDNF family receptor alpha like Gene

Gfral - GDNF family receptor alpha like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gral

基因 ID: 404194 | 基因类型: protein coding

关于 Gfral

功能概要

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in positive regulation of MAPK cascade and reduction of food intake in response to dietary excess. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Apr 2022]

Gfral 基因产物(1)

mRNA Protein Name
NM_205844.4 NP_995316.2 GDNF family receptor alpha-like precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glial cell-derived neurotrophic factor receptor activity IDA
IDA: 通过直接分析推断
28846097 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
28846098 MGI
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
28846099 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in GDF15-GFRAL signaling pathway IDA
IDA: 通过直接分析推断
32723474 MGI
involved in GDF15-GFRAL signaling pathway IMP
IMP: 通过突变表型推断
31875646 MGI
involved in negative regulation of appetite IDA
IDA: 通过直接分析推断
32723474 MGI
involved in negative regulation of appetite IMP
IMP: 通过突变表型推断
31875646 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
16086688 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
16086688 MGI
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
28953886 MGI
involved in reduction of food intake in response to dietary excess IDA
IDA: 通过直接分析推断
28846097 MGI
involved in reduction of food intake in response to dietary excess IMP
IMP: 通过突变表型推断
28846098 MGI
involved in response to metformin IMP
IMP: 通过突变表型推断
31875646 MGI
acts upstream of or within stress-activated protein kinase signaling cascade IDA
IDA: 通过直接分析推断
16086688 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
16086688 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

GDNF family receptor alpha-like

GDNF receptor alpha-like

重组 Gfral 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77947 GFRAL Protein, Mouse (HEK293, His-Avi) Q6SJE0-1 (Q20-E350) ≥95%
HY-P700449 GFRAL Protein, Mouse (HEK293, His-Myc) Q6SJE0-1 (Q20-G349) ≥95%
HY-P700728 GFRAL Protein, Mouse (Biotinylated, HEK293, His-Avi) Q6SJE0-1 (Q20-E350) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99241 Ponsegromab Inhibitor 99.41% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05390 GFRAL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gfral NCBI NCBI:389400
Macaca fascicularis Gfral NCBI NCBI:102126381
Rattus norvegicus Gfral NCBI NCBI:501023
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