GIP 蛋白, Mouse (HEK293, His)

GIP protein is a potent stimulator of insulin secretion that critically regulates glucose homeostasis by promoting insulin release from pancreatic beta cells. GIP has limited inhibitory effects on gastric acid secretion and plays dual roles in nutrient sensing and metabolic regulation, particularly in postprandial glucose metabolism. GIP Protein, Mouse (HEK293, His) is the recombinant mouse-derived GIP protein, expressed by HEK293 , with C-His labeled tag. The total length of GIP Protein, Mouse (HEK293, His) is 64 a.a., with molecular weight of 13-18 kDa.

GIP 蛋白作为胰岛素分泌的有效刺激剂，在葡萄糖稳态中发挥着至关重要的作用。其主要功能在于促进胰腺β细胞释放胰岛素，有助于调节血糖水平。相比之下，GIP对胃酸分泌的抑制作用相对有限。这种双重作用使 GIP 成为营养传感和代谢调节之间复杂相互作用的关键参与者，特别是在餐后葡萄糖代谢的背景下。该蛋白质增强胰岛素分泌的能力强调了其在控制葡萄糖代谢中的重要性，使其成为理解和潜在调节与糖尿病和胰岛素抵抗相关的代谢过程的感兴趣的目标。

Mouse

HEK293

C-His

P48756 (E22-Q85)

14607  [NCBI]

13-18 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.