GM-CSF 蛋白, Rat (HEK293, His)

GM-CSF Protein, a cytokine, promotes the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes. It functions as a monomer, interacting with the GM-CSF receptor complex, forming a dodecamer structure with two alpha, two beta, and two ligand subunits in head-to-head hexamers (By similarity). GM-CSF Protein, Rat (HEK293, His) is the recombinant rat-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM-CSF Protein, Rat (HEK293, His) is 127 a.a., with molecular weight of 17-25 kDa.

GM-CSF 蛋白是一种细胞因子，因其能够促进多个谱系的造血前体细胞（包括粒细胞、巨噬细胞、嗜酸性粒细胞和红细胞）的生长和分化而闻名。它作为单体发挥作用，并与 GM-CSF 受体复合物相互作用，该复合物由两个 α、两个 β 和两个配体亚基的两个头对头六聚体组成，形成十二聚体结构（通过相似性）。

Rat

HEK293

C-6*His

P48750 (A18-K144)

116630  [NCBI]

APTRSPNPVTRPWKHVDAIKEALSLLNDMRALENEKNEDVDIISNEFSIQRPTCVQTRLKLYKQGLRGNLTKLNGALTMIASHYQTNCPPTPETDCEIEVTTFEDFIKNLKGFLFDIPFDCWKPVQK

17-25 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.