GYPA/CD235a 蛋白, Human (His)

GYPA, also known as glycoprotein A, is a major membrane protein in red blood cells and plays an important role in the integrity of cell membranes. GYPA is a receptor for influenza virus, Plasmodium falciparum erythrocyte binding Antigen 175 (EBA-175), and hepatitis A virus (HAV). GYPA/CD235a Protein, Human (His) is the recombinant human-derived GYPA/CD235a protein, expressed by E. coli , with N-6*His labeled tag. The total length of GYPA/CD235a Protein, Human (His) is 72 a.a., with molecular weight of ~11 kDa.

GYPA，也被称为糖蛋白 A，是锚蛋白-1 复合体的关键成分，锚蛋白-1 复合体是维持红细胞膜稳定性和形状的多蛋白组装体。GYPA 是红细胞内主要的膜蛋白，对细胞膜的完整性起着重要的作用。它的N 端糖基化段突出于红细胞膜外，承载 MN 血型受体，在红细胞功能中起重要作用。GYPA 对于SLC4A1 的最佳活性尤其重要，它的存在是这种膜转运蛋白高活性所必需的。此外，GYPA 与SLC4A1 向质膜的易位有关。除了其结构作用外，GYPA 还作为流感病毒、恶性疟原虫红细胞结合抗原 175 (EBA-175) 和甲型肝炎病毒 (HAV) 的受体，突出了其多种功能。GYPA 作为同型二聚体存在，是锚蛋白-1 复合体的组成部分，与红细胞膜中的其他蛋白如 ANK1、RHCE、RHAG、SLC4A1、EPB42、GYPB 和 AQP1 协同作用，从而促进这些血细胞的整体结构完整性和功能。与 SLC4A1 的相互作用导致形成异源四聚体，强调红细胞膜复合物的合作性质。

Human

E. coli

N-6*His

A0A0C4DFT7 (L20-E91)

2993  [NCBI]

LSTTEVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPE

Approximately 11 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of Tris-based buffer, 50% Glycerol or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.