HARS/HisRS 蛋白, Human (sf9, His)

HARS is a key enzyme that coordinates the ATP-dependent attachment of histidine to the 3' end of its corresponding tRNA through the formation of an aminoacyl adenylate intermediate (His-AMP). This critical step in protein synthesis ensures the accurate incorporation of histidine into the nascent polypeptide chain. HARS/HisRS Protein, Human (sf9, His) is the recombinant human-derived HARS/HisRS protein, expressed by Sf9 insect cells , with N-His labeled tag.

HARS（组氨酰-tRNA 合成酶），也称为 HisRS，是一种关键的酶，可催化组氨酸与其相应 tRNA 3' 端的 ATP 依赖性连接，形成称为 His-AMP 的氨酰基腺苷酸中间体。这个过程对于在蛋白质合成过程中将组氨酸准确掺入不断增长的多肽链至关重要。除了其在翻译中的典型作用之外，HARS 还涉及轴突引导，这表明除了蛋白质生物合成之外，HARS 在细胞过程中还有额外的功能。它必须强调该酶在组氨酸激活中的关键作用及其在轴突引导中的有趣参与，拓宽我们对其对翻译和神经元发育的潜在贡献的理解。

Human

Sf9 insect cells

N-His

P12081-1/NP_002100.2 (A2-C509)

3035  [NCBI]

Approximately 59.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.