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  3. HHLA2 蛋白, Human (HEK293, His)

HHLA2 蛋白, Human (HEK293, His)

目录号: HY-P76971
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HHLA2 蛋白是一种关键的免疫调节剂,与 TMIGD2 相互作用,在 TCR 介导的激活过程中为 T 细胞提供重要的共刺激。这种相互作用通过 AKT 依赖性信号级联放大 T 细胞增殖和细胞因子产生,揭示了 HHLA2 在增强 T 细胞反应和免疫调节方面的作用。HHLA2 蛋白, Human (HEK293, His) 是重组的 HHLA2 蛋白,由 HEK293 表达,带有 C-His 标签。HHLA2 蛋白, Human (HEK293, His) 全长 322 个氨基酸,分子量约为 ~38.4 KDa。

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描述

HHLA2 protein, a key immune regulator, interacts with TMIGD2, providing crucial costimulation for T-cells during TCR-mediated activation. This interaction amplifies T-cell proliferation and cytokine production through an AKT-dependent signaling cascade, revealing HHLA2's role in enhancing T-cell responses and immune modulation. HHLA2 Protein, Human (HEK293, His) is the recombinant human-derived HHLA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of HHLA2 Protein, Human (HEK293, His) is 322 a.a., with molecular weight of ~38.4 KDa.

研究背景

HHLA2 蛋白是免疫调节中的关键参与者,它与 TMIGD2 发生显着的相互作用,在 T 细胞受体 (TCR) 介导的激活过程中为 T 细胞提供共刺激。这种相互作用反过来又通过 AKT 依赖性信号级联放大 T 细胞增殖和细胞因子产生。HHLA2 和 TMIGD2 之间的合作强调了增强 T 细胞反应所涉及的复杂分子机制,揭示了其在免疫调节中的作用。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q9UM44/NP_009003.1 (I23-N344)

基因 ID
蛋白结构
N-term
HHLA2 (I23-N344)
Accession # Q9UM44/NP_009003.1
His
C-term
同用名
HERV-H LTR-associating protein 2; Human endogenous retrovirus-H long terminal repeat-associating protein 2
分子量

Approximately 38.4 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

HHLA2 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HHLA2 Protein, Human (HEK293, His)
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HY-P76971
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