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  2. HHLA2 - HERV-H LTR-associating 2 Gene

HHLA2 - HERV-H LTR-associating 2 Gene

中文名称:HERV-H LTR 相关 2

种属: Homo sapiens

同用名: B7y; B7H7; B7-H5; B7-H7

基因 ID: 11148 | 基因类型: protein coding

关于 HHLA2

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,296,548-108,378,285 (from NCBI)

This gene has 9 transcripts (splice variants), 101 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 36.3), colon (RPKM 25.6) and 4 other tissues.

功能概要

该基因编码在单核细胞表面发现的蛋白质配体。编码的蛋白质被认为通过与 T 淋巴细胞上的受体结合并抑制这些细胞的增殖来调节细胞介导的免疫。交替剪接导致多个转录本变体。[RefSeq 提供,2013 年 9 月]

This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

HHLA2 基因产物(6)

mRNA Protein Name
NM_001282556.2 NP_001269485.1 HERV-H LTR-associating protein 2 isoform a precursor
NM_001282557.2 NP_001269486.1 HERV-H LTR-associating protein 2 isoform a precursor
NM_001282558.2 NP_001269487.1 HERV-H LTR-associating protein 2 isoform b precursor
NM_001282559.2 NP_001269488.1 HERV-H LTR-associating protein 2 isoform c
NM_001370244.1 NP_001357173.1 HERV-H LTR-associating protein 2 isoform a precursor
NM_007072.4 NP_009003.1 HERV-H LTR-associating protein 2 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23784006 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell costimulation IDA
IDA: 通过直接分析推断
23784006 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
23784006 GOA
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
23784006 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HHLA2 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (43 - 137)

C1-set

C1-set: Immunoglobulin C1-set domain (149 - 219)

V-set

V-set: Immunoglobulin V-set domain (233 - 331)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
蛋白主名 其他名称

HERV-H LTR-associating protein 2

human endogenous retrovirus-H long terminal repeat-associating protein 2

重组 HHLA2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76970 HHLA2 Protein, Human (HEK293, Fc) Q9UM44 (M1-N344) ≥95%
HY-P76971 HHLA2 Protein, Human (HEK293, His) Q9UM44/NP_009003.1 (I23-N344) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus HHLA2 VGNC VGNC:29843
Rattus norvegicus HHLA2 RGD RGD:11472061
Macaca mulatta HHLA2 VGNC VGNC:73377
Others HHLA2 NCBI