HVEM/TNFRSF14 蛋白, Human (HEK293, hFc)

The HVEM/TNFRSF14 Protein acts as a receptor for four ligands, including TNFSF14/LIGHT, LTA/lymphotoxin-alpha, BTLA, and CD160, forming a complex stimulatory and inhibitory signaling network. Utilizing the TRAF2-TRAF3 E3 ligase pathway, it promotes immune cell survival and differentiation. HVEM participates in bidirectional cell-cell contact signaling and delivers costimulatory signals to T cells in response to TNFSF14/LIGHT ligation. It interacts with CD160 on NK cells, enhancing anti-tumor responses. During bacterial infection, HVEM on epithelial cells responds to CD160, triggering antimicrobial responses. It down-regulates CD28 signaling in activated CD4+ T cells and engages in both cis and trans interactions with BTLA, influencing immune responses. Additionally, HVEM acts as a receptor for Herpes simplex virus 1/HHV-1. HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is the recombinant human-derived HVEM/TNFRSF14 protein, expressed by HEK293, with C-hFc labeled tag. The total length of HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is 164 a.a., with molecular weight of 48.5 kDa.

HVEM/TNFRSF14 是四种不同配体的受体，错综复杂地协调着刺激和抑制信号通路的复杂网络。配体，包括 TNFSF14/LIGHT、同源三聚体 LTA/淋巴毒素-α 以及免疫球蛋白超家族成员 BTLA 和 CD160，共同定义了这个复杂的信号网络。HVEM/TNFRSF14 通过 TRAF2-TRAF3 E3 连接酶途径发挥作用，发出促进免疫细胞存活和分化的信号，在抗原呈递细胞和淋巴细胞之间的双向细胞-细胞接触信号传导中发挥关键作用。TNFSF14/LIGHT 连接后，HVEM/TNFRSF14 向 T 细胞传递共刺激信号，促进细胞增殖和效应功能。与 NK 细胞上的 CD160 相互作用可增强 IFNG 的产生和抗肿瘤免疫反应。在细菌感染中，HVEM/TNFRSF14 作为上皮细胞上皮内淋巴细胞 CD160 的信号传导受体，触发抗菌蛋白和促炎细胞因子的产生。此外，HVEM/TNFRSF14通过在活化的CD4+T细胞上结合CD160，下调CD28共刺激信号传导，限制记忆和同种抗原特异性免疫反应。HVEM/TNFRSF14 与 BTLA 表现出顺式和反式相互作用，在适应性免疫反应过程中的免疫调节和生存信号传导中发挥多种作用。此外，作为单纯疱疹病毒 1/HHV-1 的受体，HVEM/TNFRSF14 与微生物感染有关。

Human

HEK293

C-hFc

Q92956 (L39-V202)

8764  [NCBI]

LPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAMGLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPGTFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWV

48.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.