TNFRSF14 - TNF receptor superfamily member 14 Gene

中文名称：TNF 受体超家族成员 14

种属: Homo sapiens

同用名: TR2; ATAR; HVEA; HVEM; CD270; LIGHTR

基因 ID: 8764 | 基因类型: protein coding

关于 TNFRSF14

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:2,554,234-2,563,829 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 538 orthologues, 21 paralogues and is associated with 66 phenotypes. Ubiquitous expression in spleen (RPKM 22.9), duodenum (RPKM 21.7) and 23 other tissues.

功能概要

该基因编码 TNF (肿瘤坏死因子) 受体超家族的成员。编码的蛋白质在激活炎症和抑制性 T 细胞免疫反应的信号转导通路中发挥作用。它结合单纯疱疹病毒 (HSV) 病毒包膜糖蛋白 D (gD) ，介导其进入细胞。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFRSF14 基因产物(2)

mRNA	Protein	Name
NM_001297605.2	NP_001284534.1	tumor necrosis factor receptor superfamily member 14 isoform 2 precursor
NM_003820.4	NP_003811.2	tumor necrosis factor receptor superfamily member 14 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytokine binding	IPI IPI: 通过物理相互作用推断	27152329	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9153189	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	11279055	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in T cell costimulation	IDA IDA: 通过直接分析推断	10754304	GOA
involved in negative regulation of adaptive immune memory response	IDA IDA: 通过直接分析推断	18193050	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	18193050	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFRSF14 蛋白结构

TNFR_c6

0
100
200
283 a.a.

蛋白主名

其他名称

tumor necrosis factor receptor superfamily member 14

CD40-like protein

重组 TNFRSF14 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7366	HVEM/TNFRSF14 Protein, Human (Sf9, Fc)	Q92956 (L39-K184)	≥95%
HY-P70489	HVEM/TNFRSF14 Protein, Human (HEK293, His)	Q92956 (L39-V202)	≥95%
HY-P700452	HVEM/TNFRSF14 Protein, Human (HEK293, hFc)	Q92956 (L39-V202)	≥95%

关联疾病

疾病名称

别名

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Herpetic Whitlow

Herpetic Felon

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

Acute Retinal Necrosis Syndrome

Acute Retinal Necrosis

Retinal Necrosis Syndrome, Acute

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14806	TNFRSF14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TNFRSF14	VGNC	VGNC:80387
Macaca mulatta	TNFRSF14	VGNC	VGNC:78585
Canis familiaris	TNFRSF14	VGNC	VGNC:47658
Rattus norvegicus	TNFRSF14	RGD	RGD:1310115
Mus musculus	TNFRSF14	MGD	MGI:2675303
Others	TNFRSF14	NCBI

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