1. Biology Dictionary
  2. Yeast Surface Display

Yeast Surface Display酵母展示法

释义:

Yeast Surface Display is used to study molecular binding properties by displaying proteins on the surface of yeast. It is commonly applied in antibody screening, receptor-ligand interactions, and drug development. By fusing a protein secretion signal sequence, proteins are displayed on the surface of the yeast S. cerevisiae. Although the method is limited by the low efficiency of the yeast display system, it can be combined with cell sorting technologies (such as FACS) to isolate cells displaying specific binding properties, enabling efficient screening.

酵母展示法用于通过酵母表面展示蛋白质研究分子结合特性,常应用于抗体筛选、受体配体相互作用以及药物开发等领域。通过融合蛋白分泌信号序列,将蛋白质展示于酵母 S. cerevisiae 的表面。尽管该方法受限于酵母展示系统的低效率,但结合细胞分选技术 (如 FACS) 可以分离出显示特定结合特性的细胞,从而实现高效筛选。

MCE 生物医学词典

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