Hyaluronidase-1/HYAL1 蛋白, Human (HEK293, His)

Hyaluronidase-1/HYAL1 Protein is implicated in tumor progression, suggesting its role in cancer advancement. It also inhibits TGFB1-enhanced cell growth, revealing its regulatory function. HYAL1's dual impact on promoting tumor progression and inhibiting specific cellular processes underscores its complex involvement in cellular behavior and potential significance in tumorigenesis. Hyaluronidase-1/HYAL1 Protein, Human (HEK293, His) is the recombinant human-derived Hyaluronidase-1/HYAL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Hyaluronidase-1/HYAL1 Protein, Human (HEK293, His) is 414 a.a., with molecular weight of 50-65 kDa.

Hyaluronidase-1/HYAL1 蛋白作为肿瘤进展的潜在贡献者出现，表明它参与了促进癌症进展的复杂机制。此外，它还具有阻碍 TGFB1 增强的细胞生长的能力，强调了其抑制特定细胞过程的调节功能。其对促进肿瘤进展和抑制 TGFB1 增强的细胞生长的双重作用强调了 HYAL1 参与细胞行为的复杂性，并强调了其在肿瘤发生中的潜在意义。

Measured in a cell proliferation assay using DU145 cells. The ED₅₀ for this effect is ≤1 ng/mL, corresponding to a specific activity is ≥1×10⁶ units/mg.

Human

HEK293

C-6*His

Q12794-1 (F22-W435)

3373  [NCBI]

FRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW

Approximately 50-65 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.