IL-13R alpha 1 蛋白, Human (HEK293, His)

The IL13RA1 protein is critical in immune signaling and binds with low affinity to IL13. It binds to IL4RA to form a functional IL13 receptor for cellular responses. IL-13R alpha 1 Protein, Human (HEK293, His) is the recombinant human-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

IL13RA1 蛋白在免疫信号传导中发挥着至关重要的作用，与白细胞介素 13 (IL13) 表现出低亲和力结合。当与 IL4RA 结合时，它形成 IL13 的功能性受体，促进细胞对该细胞因子的反应。此外，IL13RA1 与 IL4RA 一起作为白细胞介素 4 (IL4) 信号转导的替代辅助蛋白，尽管它不能取代 IL2RG 增强白细胞介素 2 (IL2) 结合活性的功能。IL-13 受体是一个复杂的组件，包含 IL4R、IL13RA1 和可能的其他组件，表明该信号系统的复杂结构。此外，IL13RA1 与 TRAF3IP1 相互作用，表明它参与多种细胞过程。此外，IL13RA1 与 IL4 相互作用，强调了其在介导白介素信号通路反应中的多方面作用。

Human

HEK293

C-6*His

P78552-1 (G22-T343)

3597  [NCBI]

GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST

55-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.