2. Gene
  3. IL13RA1 - interleukin 13 receptor subunit alpha 1 Gene

IL13RA1 - interleukin 13 receptor subunit alpha 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 13 受体亚基 α 1

种属: Homo sapiens

同用名: NR4; CT19; CD213A1; IL-13Ra

基因 ID: 3597 | 基因类型: protein coding

关于 IL13RA1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,727,606-118,805,228 (from NCBI)

This gene has 4 transcripts (splice variants), 418 orthologues and 23 paralogues. Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是白介素 13 受体的一个亚基。该亚基与 IL4 受体 α 形成受体复合物，后者是 IL13 和 IL4 受体共有的亚基。该亚基是 IL13 受体的主要 IL13 结合亚基，也可能是 IL4 受体的组成部分。该蛋白已被证明与酪氨酸激酶 Tyk2 结合，因此可能介导信号传导过程，导致 IL13 和 IL4 诱导的 JAK1、STAT3 和 STAT6 激活。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase Tyk2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

IL13RA1 基因产物(1)

mRNA Protein Name
NM_001560.3 NP_001551.1 interleukin-13 receptor subunit alpha-1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12935900 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL13RA1 蛋白结构

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (128 - 223)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
蛋白主名 其他名称

interleukin-13 receptor subunit alpha-1

CD213a1 antigen

IL13RA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IL13RA1 P78552 IL13 Homo sapiens P35225
ITC
18243101
Intra IL13RA1 P78552 IL13 Homo sapiens P35225
X-Ray Diffraction
18243101
Intra IL13RA1 P78552 IL4 Homo sapiens P05112
ITC
18243101
Intra IL13RA1 P78552 IL4 Homo sapiens P05112
X-Ray Diffraction
18243101
Intra IL13RA1 P78552 TRAF3IP1 Homo sapiens Q8TDR0
Y3H
12935900
Intra IL13RA1 P78552 TRAF3IP1 Homo sapiens Q8TDR0
Anti Tag CoIP
12935900
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL13RA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72594 IL-13R alpha 1 Protein, Human (HEK293, His) P78552-1 (G22-T343) ≥95%
HY-P78163 IL-13R alpha 1 Protein, Human (Biotinylated, HEK293, His-Avi) P78552-1 (A27-T343) ≥95%

关联疾病

疾病名称 别名
Monofixation Syndrome
Interstitial Lung Disease

Ild

Lung Diseases, Interstitial

Lung Diseases Interstitial

Interstitial Lung Diseases
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Syndromic X-Linked Intellectual Disability Cabezas Type

Cabezas Syndrome

Syndromic X-Linked Mental Retardation 15

Mental Retardation, X-Linked, Syndromic 15

Mrss

Mrxs15

Mrxsc

X-Linked Mental Retardation With Short Stature

X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait

Mental Retardation, X-Linked, With Short Stature

Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
High Grade Glioma

Malignant Glioma

Glial Cell Tumor

Glioma, Malignant

Malignant Neuroglial Tumor

Neuroglial Tumor

Glioma

Malignant Gliomas
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99870 Eblasakimab ≥99.0% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IL13RA1 RGD RGD:628741
Mus musculus IL13RA1 MGD MGI:105052
Bos taurus IL13RA1 VGNC VGNC:55053
Felis catus IL13RA1 VGNC VGNC:67758
Canis familiaris IL13RA1 VGNC VGNC:41937
Macaca fascicularis IL13RA1 NCBI NCBI:102135058
Others IL13RA1 NCBI
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