IL-13R alpha 1 蛋白, Rat (HEK293, Fc)

Interleukin 13 receptor subunit alpha 1 is a subunit of the interleukin 13 receptor. Interleukin 13 receptor subunit alpha 1 has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. IL-13R alpha 1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-13R alpha 1 Protein, Rat (HEK293, Fc) is 316 a.a., with molecular weight of 90 KDa.

Interleukin 13 receptor subunit alpha 1 是白细胞介素 13 受体的一个亚单位，该亚单位与 IL4 受体 α 形成受体复合物，IL13 和 IL4 受体共享的亚单位，这种亚单位作为 IL13 受体的主要 IL13 结合亚单位，也可能是 IL4 受体的组成部分。Interleukin 13 receptor subunit alpha 1 已被证明与酪氨酸激酶 TYK2 结合，因此可能介导导致 IL13 和 IL4 诱导的 JAK1、STAT3 和 STAT6 激活的信号过程。Interleukin 13 receptor subunit alpha 1 使蛋白质结合并参与细胞表面受体信号通路^{[1][2][3][4][5]}。

Measured by its binding ability in a functional ELISA. When recombinant rat IL-13R alpha 1 at 4 µg/mL (100 µL/well) can bind recombinant human IL-13. The ED₅₀ for this effect is 25.58 ng/mL.

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  Measured by its binding ability in a functional ELISA. When recombinant rat IL-13R alpha 1 at 4 µg/mL (100 µL/well) can bind recombinant human IL-13 .The ED₅₀ for this effect is 25.58 ng/mL.

Rat

HEK293

C-hFc

Q561K3 (T27-T342)

100360218  [NCBI]

TEVQPPVTNLSVSVENLCTIVWTWSPPEGASPNCSLRYFSHFDDQQDKKIAPETRRKKELPLNEKICLQVGSQCSTNESEKPSPLVKKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGKNTSPDTNYTLYYWYSSLGKSLQCENIHREGQHIGCSFKLTKVESNYEHHNIQIMVKDNAGKIRPSYKIVSFTSNVKPGPPHIKHLFLKNGALFVQWKNPQNFSSRCLSYEVEVNSTQTDSYNSNSLEVEEDKCQNSEFDRNMEGASCFISPGVLANTVYTVRVRVKTNKLCFDDNDLWSNWSEALSIGKEPNST

approximately 90 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.