IL-15R alpha & IL-15 蛋白, Mouse (HEK293, His)

IL-15R alpha Protein, the high-affinity receptor for interleukin-15, crucially signals in cis and trans, presenting IL-15 to neighboring IL2RG-expressing cells. In neutrophils, it activates SYK kinase, essential for IL-15-induced phagocytosis in a SYK-dependent manner. IL-15R alpha forms a heterotrimer with IL2RB and IL2RG, capable of self-association. Interactions with SYK underscore its intricate involvement in cellular signaling pathways. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-15R alpha & IL-15 protein, expressed by HEK293 , with C-His labeled tag. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His), has molecular weight of ~36 kDa.

IL-15R α 蛋白作为白介素 15 的高亲和力受体出现，在细胞信号传导中发挥着至关重要的作用。该受体表现出顺式和反式信号传递的能力，其中来自一个细胞亚群的 IL15R 将白细胞介素 15 呈递给邻近的表达 IL2RG 的细胞。在中性粒细胞中，IL-15R α 结合并激活激酶 SYK，以响应白细胞介素 15 的刺激，并且它对于 IL-15 以 SYK 依赖性方式诱导的吞噬作用至关重要。白介素 15 受体 IL15R 形成由 IL15RA、IL2RB 和 IL2RG 组成的异源三聚体，其中 IL15RA 能够自我缔合（通过相似性）。此外，IL-15R α 与 SYK 相互作用，进一步凸显其在细胞信号传导通路中的复杂参与（通过相似性）。

Mouse

HEK293

C-His

Q60819-1 (G33-K205) & P48346 (G30-S162)

16169  [NCBI] & 16168  [NCBI]

Approximately 36 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.