Il15 - interleukin 15 Gene

中文名称：白细胞介素 15

种属: Mus musculus

同用名: IL-15

关于 Il15

功能概要

该基因编码白细胞介素蛋白家族的多效细胞因子，在先天性和适应性细胞稳态以及外周免疫功能中发挥重要作用。编码的蛋白质经过蛋白水解处理，产生成熟的细胞因子，刺激自然杀伤细胞的增殖。过表达编码蛋白的转基因小鼠表现出处于幼稚状态的记忆 CD8+ T 细胞数量增加，并增强了对细菌感染的保护。缺乏编码蛋白的小鼠表现出对减毒分枝杆菌菌株的保护受损。 [RefSeq 提供，2016 年 8 月]

This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against Bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]