2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-1RA
  6. IL-1RA/IL-1RN 蛋白, Rat (His, solution)

IL-1RA/IL-1RN 蛋白, Rat (His, solution)

目录号: HY-P73894
COA 产品使用指南 技术支持

IL-1RA/IL-1RN 突变蛋白是白细胞介素 1 家族的有效抗炎拮抗剂，专门针对促炎细胞因子 IL1B 和 IL1A。这种突变变体旨在增强抑制能力，紧密保护宿主免受免疫失调的影响，并防止 IL1 因先天刺激物而引发不受控制的全身炎症。IL-1RA/IL-1RN 蛋白, Rat (His, solution) 是重组的 IL-1RA/IL-1RN 蛋白，由 E. coli 表达，带有 C-His 标签。

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规格 价格 是否有货 数量
2 μg ￥550 In-stock
10 μg ￥1500 In-stock
50 μg ￥4200 In-stock
100 μg ￥7100 询价
> 100 μg   询价  

* Please select Quantity before adding items.

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描述

IL-1RA/IL-1RN mutant proteins are potent anti-inflammatory antagonists of the interleukin 1 family, specifically targeting the proinflammatory cytokines IL1B and IL1A. This mutant variant is designed for enhanced suppressive capacity, tightly protecting the host from immune dysregulation and preventing IL1 from triggering uncontrolled systemic inflammation in response to innate stimulators. IL-1RA/IL-1RN Protein, Rat (His, solution) is the recombinant rat-derived IL-1RA/IL-1RN protein, expressed by E. coli , with C-His labeled tag.
研究背景

IL-1RA/IL-1RN 突变蛋白在 IL-1 家族中充当有效的抗炎拮抗剂，专门针对促炎细胞因子，如 IL-1β/IL1B 和 IL-1α/IL1A。这种突变体经过精心设计，可增强其抑制能力，在保护宿主免受免疫失调和防止IL1响应各种先天刺激剂（包括病原体）而引发不受控制的全身炎症方面发挥着关键作用。通过提供针对 IL1 介导的炎症反应的优化防御，突变蛋白对维持免疫平衡和防止过度炎症做出了重大贡献。
种属

Rat
表达系统

E. coli
标签

C-His
蛋白编号

P25086 (H27-Q178)
基因 ID
同用名
Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; Il1rn
分子量

Approximately 19.01 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

溶液
组分

Supplied as a sterile PBS, pH 7.4.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

N/A.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.
文件资料

COA (208 KB)

产品使用指南 (1213 KB)

IL-1RA/IL-1RN Protein, Rat (His, solution) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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目录号：
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