2. Gene
  3. Il1rn - interleukin 1 receptor antagonist Gene

Il1rn - interleukin 1 receptor antagonist Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: IL-1ra

基因 ID: 60582 | 基因类型: protein coding

关于 Il1rn

功能概要

Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; and transient cerebral ischemia. Biomarker of encephalitis and pneumonia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Il1rn 基因产物(1)

mRNA Protein Name
NM_022194.2 NP_071530.1 interleukin-1 receptor antagonist protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-1 receptor binding IDA
IDA: 通过直接分析推断
1834644 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carboxylic acid metabolic process IEP
IEP: 通过表达模式推断
9685640 RGD
involved in cellular response to norepinephrine stimulus IEP
IEP: 通过表达模式推断
19818755 RGD
involved in chronic inflammatory response to antigenic stimulus IEP
IEP: 通过表达模式推断
15050649 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
14603373 RGD
involved in fever generation IMP
IMP: 通过突变表型推断
16455768 RGD
involved in memory IMP
IMP: 通过突变表型推断
15050649 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16038625 RGD
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
21244430 RGD
involved in negative regulation of glutamate secretion IMP
IMP: 通过突变表型推断
12667655 RGD
involved in negative regulation of membrane potential IDA
IDA: 通过直接分析推断
20554014 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: 通过突变表型推断
12667655 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
22117073 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
8906613 RGD
involved in response to interleukin-4 IEP
IEP: 通过表达模式推断
8409406 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
17138728 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
15751073 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
22117073 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15837124 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
17138728 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-1 receptor antagonist protein

IL-1RN

IL1 inhibitor

IRAP

重组 Il1rn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73187 IL-1RA/IL-1RN Protein, Rat (HEK293, Fc) P25086 (H27-Q178) ≥95%
HY-P73894 IL-1RA/IL-1RN Protein, Rat (His, solution) P25086 (H27-Q178) ≥95%
HY-P75853 IL-1RA/IL-1RN Protein, Cynomolgus (His) NP_001270468.1 (R26-E177) ≥95%
HY-P73894A IL-1RA/IL-1RN Protein, Rat (C-His) P25086 (H27-Q178) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06727 IL1RN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il1rn NCBI NCBI:3557
Macaca fascicularis Il1rn NCBI NCBI:102126145
Mus musculus Il1rn NCBI NCBI:16181
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