IL-1RL2 蛋白, Mouse (A158V, HEK293, His)

The IL-1RL2 protein functions as a receptor for interleukin 36 (IL36A, IL36B, and IL36G) and upon binding forms a complex with the coreceptor IL1RAP. This IL-36 receptor complex plays a key role in activating NF-κ-B, MAPK, and other signaling pathways. IL-1RL2 Protein, Mouse (A158V, HEK293, His) is the recombinant mouse-derived IL-1RL2 protein, expressed by HEK293 , with C-6*His labeled tag.

IL-1RL2 蛋白是白细胞介素 36（IL36A、IL36B 和 IL36G）的受体。与白细胞介素 36 结合后，它与辅助受体 IL1RAP 形成复合物，构成白细胞介素 36 受体复合物。该复合物在介导 NF-κ-B、MAPK 和其他信号通路的 IL-36 依赖性激活中发挥着关键作用。IL-36 信号系统被认为存在于上皮屏障中，参与局部炎症反应并与 IL-1 系统有相似之处。IL-1RL2 似乎参与皮肤的炎症反应，可能诱导 IL-23/IL-17/IL-22 通路。这些相互作用凸显了 IL-1RL2 在免疫反应调节中的重要性，特别是在上皮屏障和局部炎症的背景下。

Mouse

HEK293

C-6*His

Q9ERS7 (D22-R338, A158V)

107527  [NCBI]

DTCEDIFMHNVIISEGQPFPFNCTYPPETNGAVNLTWYKTPSKSPVSNNRHLRVHQDQTWILFLPLTLEDSGIYQCVIRNAHNCYQIAVNLTVLKNHWCDSSMEGSPVNSPDVYQQILPIGKSGSLNCHLYFPESCVLDSIKWYKGCEEIKAGKKYSPSGAKLLVNNVAVEDGGSYACSARLTHLGRHFTIRNYIAVNTKEVEYGRRIPNITYPKNNSIEVPLGSTLIVNCNITDTKENTNLRCWRVNNTLVDDYYKDSKRIQEGIETNVSLRDQIRYTVNITFLKVKMEDYGRPFTCHAGVSAAYIILIYPVPDFR

50-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.