IL-22R alpha 1 蛋白, Cynomolgus (HEK293, His)

IL-22R α 1 and IL-10R β together form IL20, IL22 and IL24 receptor complexes, activating different signaling pathways. Within the IL22 receptor, IL-22R α 1 binds to IL10RB and mediates IL22 signaling through the JAK/STAT and MAPK1/MAPK3/Akt pathways. IL-22R alpha 1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-22R alpha 1 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-22R alpha 1 Protein, Cynomolgus (HEK293, His) is 208 a.a., with molecular weight of 38-48 kDa.

IL-22R α 1 是 IL20、IL22 和 IL24 受体的关键成分，在介导这些白细胞介素激活的信号传导途径中发挥着至关重要的作用。它与 IL10RB 形成异二聚体，构成 IL22 受体并通过 JAK/STAT 途径促进 IL22 信号传导。IL-22R α1 也是另一个受体复合物的一部分，与 IL20RB 一起，响应 IL20 和 IL24，导致 STAT 的激活。除了 JAK/STAT 途径之外，IL-22 还可诱导 MAPK1/MAPK3 和 Akt 激酶激活。值得注意的是，IL-22R α 1 有助于 IL24 的抗血管生成活性，并抑制 IL24 诱导的内皮细胞管形成和分化。在其与 IL10RB 和 IL20RB 的功能性异二聚体关联中，IL-22R α 1 强调了其在介导对 IL20、IL22 和 IL24 的多种细胞反应中的关键作用。

Cynomolgus IL-22R alpha 1, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-22, His Tag with an affinity constant of 58-61 nM as determined in SPR assay (Biacore T200).

Cynomolgus

HEK293

C-His

A0A2K5TKX9 (P18-T225)

102117911

38-48 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.