IL-27 蛋白, Mouse (HEK293, His, solution)

The IL-27 protein together with IL23A forms IL-23 interleukin, a key cytokine in innate and adaptive immunity. It is associated with infection responses, binds to IL12RB1 and IL23R receptor complexes, and activates Jak-Stat signaling. IL-27 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived IL-27, expressed by HEK293 , with C-10*His labeled tag. ,

IL-12 与 IL23A 结合形成 IL-23 白细胞介素，这是一种异二聚体细胞因子，在先天性和适应性免疫中发挥重要作用。这种细胞因子参与外周组织感染的急性反应，并与由 IL12RB1 和 IL23R 组成的异二聚体受体复合物结合，激活 Jak-Stat 信号级联。IL-23 刺激记忆 T 细胞而不是幼稚 T 细胞，并促进促炎细胞因子的产生。它已被确定为自身免疫性炎症的一个促成因素，可能导致自身免疫性炎症疾病并与肿瘤发生有关。此外，IL-12 还可作为激活的 T 细胞和 NK 细胞的生长因子，增强 NK/淋巴因子激活的杀伤细胞的裂解活性，并刺激静息 PBMC 产生干扰素-γ。

1.Measured by its binding ability in a functional ELISA. Immobilized mouse IL27-His at 10 μg/mL (100 μl/well) can bind human IL27RA-Fc and the EC₅₀ is 0.26-0.62 μg/mL.
2.Measured in antiviral assay using HepG2 cells infected with vesicular stomatitisvirus (VSV) and the ED₅₀ is ≤10ng/mL.

Mouse

HEK293

C-10*His

O35228 (Y19-P228) &GSGSGGSGGSGSGKL& Q8K3I6 (F29-S234)

50498&246779

YTETALVALSQPRVQCHASRYPVAVDCSWTPLQAPNSTRSTSFIATYRLGVATQQQSQPCLQRSPQASRCTIPDVHLFSTVPYMLNVTAVHPGGASSSLLAFVAERIIKPDPPEGVRLRTAGQRLQVLWHPPASWPFPDIFSLKYRLRYRRRGASHFRQVGPIEATTFTLRNSKPHAKYCIQVSAQDLTDYGKPSDWSLPGQVESAPHKPGSGSGGSGGSGSGKLFPTDPLSLQELRREFTVSLYLARKLLSEVQGYVHSFAESRLPGVNLDLLPLGYHLPNVSLTFQAWHHLSDSERLCFLATTLRPFPAMLGGLGTQGTWTSSEREQLWAMRLDLRDLHRHLRFQVLAAGFKCSKEEEDKEEEEEEEEEEKKLPLGALGGPNQVSSQVSWPQLLYTYQLLHSLELVLSRAVRDLLLLSLPRRPGSAWDS

Approximately 60 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.