Inhibin beta C chain/INHBC 蛋白, Human (HEK293, His)

The inhibin beta C chain (INHBC) protein complexly regulates the inhibin and activin systems and balances follicle-stimulating hormone secretion. Its key roles span a variety of physiological processes, including hormone secretion, cell development, insulin release, and bone growth, depending on the specific subunit composition. Inhibin beta C chain/INHBC Protein, Human (HEK293, His) is the recombinant human-derived Inhibin beta C chain/INHBC protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Inhibin beta C chain/INHBC Protein, Human (HEK293, His) is 334 a.a., with molecular weight of 47-56 kDa&34-38 kDa&16 kDa.

INHBC 蛋白作为抑制素和激活素系统的一部分，处于复杂调节途径的连接点，协调抑制和激活垂体促卵泡素分泌的双重作用。抑制素和激活素的多方面作用，其中 INHBC 发挥着关键作用，跨越多种生理过程，包括下丘脑和垂体激素分泌、性腺激素分泌、生殖细胞发育和成熟、红细胞分化、胰岛素分泌、神经细胞存活、胚胎轴发育和骨生长，取决于特定的亚基组成。在这种复杂的相互作用中，抑制素（以抑制素 A 和抑制素 B 等异二聚体为代表）作为与激活素功能相反的对应物出现。在结构上，INHBC 通过与 α 和 β 亚基结合以同二聚体或异二聚体构型存在，并通过一个或多个二硫键错综复杂地连接。值得注意的是，抑制素表现为包含一个α和一个β亚基的异二聚体，而激活素，无论是同二聚体还是异二聚体，都完全由β亚基组成。这种结构多样性强调了 INHBC 在塑造全面且精细调整的生理景观时精心策划的细致入微的调节机制。

Human

HEK293

C-6*His

P55103 (T19-S352)

3626  [NCBI]

TPRAGGQCPACGGPTLELESQRELLLDLAKRSILDKLHLTQRPTLNRPVSRAALRTALQHLHGVPQGALLEDNREQECEIISFAETGLSTINQTRLDFHFSSDRTAGDREVQQASLMFFVQLPSNTTWTLKVRVLVLGPHNTNLTLATQYLLEVDASGWHQLPLGPEAQAACSQGHLTLELVLEGQVAQSSVILGGAAHRPFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGCS

47-56 kDa&34-38 kDa&16 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM Tris-HCl, 10% Trehalose, 2% Mannitol, 0.05% Tween 80, pH 8.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.