Jagged-1/JAG1 蛋白, Mouse (Myc, His-SUMO)

Jagged-1/JAG1 protein is a multifunctional ligand that binds to multiple Notch receptors and mediates Notch signaling.It influences cell fate decisions during hematopoiesis, spans early and late mammalian cardiovascular development, and regulates myoblast differentiation.Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Jagged-1/JAG1 protein, expressed by E.coli , with C-Myc, N-SUMO, N-10*His labeled tag.

Jagged-1 (JAG1) 作为一种多功能配体，与多个 Notch 受体结合并参与 Notch 信号传导的介导。它的参与延伸到造血过程中细胞命运决定的潜在作用，并跨越哺乳动物心血管发育的早期和晚期阶段。此外，JAG1 展示了调节成肌细胞分化的能力，强调了其对不同细胞过程的调节影响。此外，它可能在成纤维细胞生长因子诱导的血管生成的调节中发挥作用。通过与 NOTCH1、NOTCH2 和 NOTCH3 的相互作用，JAG1 有助于 Notch 信号传导的复杂协调，突显其在细胞反应和发育途径中的重要性。

Mouse

E. coli

C-Myc;N-SUMO;N-10*His

Q9QXX0 (G33-E334)

16449  [NCBI]

GQFELEILSMQNVNGELQNGNCCGGVRNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTIQPDSIIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPNCE

Approximately 53.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in PBS, 6% Trehalose, pH 7.4 or 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.