2. Gene
  3. Jag1 - jagged 1 Gene

Jag1 - jagged 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Htu; Ozz; ABE2; Ser-1; Gena228; Gsfabe2

基因 ID: 16449 | 基因类型: protein coding

关于 Jag1

功能概要

Enables Notch binding activity. Involved in several processes, including circulatory system development; glomerular visceral epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 基因产物(1)

mRNA Protein Name
NM_013822.5 NP_038850.1 protein jagged-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
10551863 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15574878 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
15574878 MGI
acts upstream of or within Notch signaling pathway IGI
IGI: 通过遗传相互作用推断
25406395 MGI
involved in Notch signaling pathway IMP
IMP: 通过突变表型推断
19509466 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
11181574 MGI
involved in aorta morphogenesis IMP
IMP: 通过突变表型推断
19509466 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: 通过突变表型推断
10196361 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
10196361 MGI
involved in cardiac neural crest cell development involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19509466 MGI
involved in cardiac right ventricle morphogenesis IMP
IMP: 通过突变表型推断
19509466 MGI
involved in cardiac septum morphogenesis IMP
IMP: 通过突变表型推断
19509466 MGI
acts upstream of or within ciliary body morphogenesis IMP
IMP: 通过突变表型推断
23676271 MGI
involved in distal tubule development IEP
IEP: 通过表达模式推断
15821257 MGI
involved in endocardial cushion cell development IMP
IMP: 通过突变表型推断
19509466 MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IMP
IMP: 通过突变表型推断
16495313 MGI
involved in inner ear development IMP
IMP: 通过突变表型推断
19389353 MGI
involved in loop of Henle development IEP
IEP: 通过表达模式推断
15821257 MGI
acts upstream of or within morphogenesis of an epithelial sheet IMP
IMP: 通过突变表型推断
11861489 MGI
involved in negative regulation of endothelial cell differentiation IDA
IDA: 通过直接分析推断
25535084 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
15060169 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
involved in nephron development IMP
IMP: 通过突变表型推断
23806616 MGI
acts upstream of neuroendocrine cell differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
20081190 MGI
involved in podocyte development IMP
IMP: 通过突变表型推断
23806616 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
10958687 MGI
acts upstream of or within positive regulation of myeloid cell differentiation IDA
IDA: 通过直接分析推断
15845452 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
23980096 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19509466 MGI
acts upstream of or within regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
25406395 MGI
involved in response to muramyl dipeptide IDA
IDA: 通过直接分析推断
21156799 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
24715457 MGI
located in apical part of cell IDA
IDA: 通过直接分析推断
15821257 MGI
located in apical plasma membrane IDA
IDA: 通过直接分析推断
24715457 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16000382 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein jagged-1

Serrate-1

重组 Jag1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71633 Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) Q9QXX0 (G33-E334) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1846A Jagged-1 (188-204) (TFA) Agonist 99.89% 否
HY-P1846 Jagged-1 (188-204) Agonist / 否
HY-RS07012 JAG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Jag1 NCBI NCBI:182
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z