1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. JAM-A/CD321 Immunoglobulin-like Cell Adhesion Molecules
  5. Junctional Adhesion Molecule A (JAM-A)
  6. JAM-A/CD321 蛋白, Mouse (HEK293, His)

JAM-A/CD321 蛋白, Mouse (HEK293, His)

目录号: HY-P78322
产品使用指南

JAM-A/CD321 蛋白对于上皮紧密连接的形成至关重要,并且存在于原始细胞连接处,在那里它招募 PARD3。这种关联可能会阻碍 PARD3-JAM1 相互作用,从而阻碍紧密连接组装。JAM-A/CD321 蛋白, Mouse (HEK293, His) 是重组的 JAM-A/CD321 蛋白,由 HEK293 表达,带有 C-His 标签。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

The JAM-A/CD321 protein is critical for the formation of epithelial tight junctions and is present at primitive cell junctions where it recruits PARD3.This association may hinder PARD3-JAM1 interaction and thus tight junction assembly.JAM-A/CD321 Protein, Mouse (HEK293, His) is the recombinant mouse-derived JAM-A/CD321 protein, expressed by HEK293 , with C-His labeled tag.

研究背景

JAM-A/CD321 蛋白在上皮紧密连接的形成中起着至关重要的作用,并且存在于原始细胞连接的早期,在那里它招募 PARD3。PARD6-PARD3 复合物的结合可能阻碍 PARD3 和 JAM1 之间的相互作用,从而阻止紧密连接的组装。此外,JAM-A 参与调节单核细胞迁移,有助于上皮屏障的完整性。作为整合素 α-L/β-2 的配体,它参与记忆 T 细胞和中性粒细胞的迁移。此外,JAM-A 参与血小板活化并与 MPDZ 的第九个 PDZ 结构域相互作用。PARD3 和 PARD6B 之间的关联可能会破坏其与 PARD3 第一个 PDZ 结构域的相互作用。此外,JAM-A 与 ITGAL 相互作用(通过 I 结构域),进一步强调了它在细胞过程中的多方面参与。

种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

O88792 (K27-G238)

基因 ID
蛋白结构
N-term
JAM-A (K27-G238)
Accession # O88792
His
C-term
同用名
JAM-A; JAM-1; CD321; JAM; JCAM; JCAM1; KAT; PAM-1; F11 receptor; F11R; PAM-1KAT
分子量

36-42 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
JAM-A/CD321 Protein, Mouse (HEK293, His)
目录号:
HY-P78322
需求量: