2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. JAM-A/CD321 Immunoglobulin-like Cell Adhesion Molecules
  6. Junctional Adhesion Molecule A (JAM-A)
  7. JAM-A/CD321 蛋白, Rat (HEK293, Fc)

JAM-A/CD321 蛋白, Rat (HEK293, Fc)

目录号: HY-P73854
产品使用指南

JAM-A/CD321 蛋白对于上皮细胞中紧密连接的形成至关重要，参与早期连接发育和招募 PARD3。然而，PARD6-PARD3复合物的形成可能会阻碍PARD3-JAM1相互作用，从而阻止紧密连接组装。JAM-A/CD321 蛋白, Rat (HEK293, Fc) 是重组的 JAM-A/CD321 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

The JAM-A/CD321 protein is critical for the formation of tight junctions in epithelial cells, participating in early junction development and recruiting PARD3. However, the formation of PARD6-PARD3 complex may hinder PARD3-JAM1 interaction, thus preventing tight junction assembly. JAM-A/CD321 Protein, Rat (HEK293, Fc) is the recombinant rat-derived JAM-A/CD321 protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

JAM-A/CD321 蛋白在上皮细胞紧密连接的形成中起着至关重要的作用。它参与细胞连接发育的早期阶段并招募 PARD3。然而，PARD6-PARD3复合物的形成可能会阻碍PARD3和JAM1之间的相互作用，从而导致紧密连接组装受到阻碍。此外，JAM-A/CD321 参与调节单核细胞的迁移，这对于维持上皮屏障的完整性至关重要。它还充当整合素 α-L/β-2 的配体，促进记忆 T 细胞和中性粒细胞的迁移。此外，JAM-A/CD321 与 MPDZ 的第九个 PDZ 结构域和 PARD3 的第一个 PDZ 结构域相互作用，PARD3 和 PARD6B 之间的关联可能会破坏这种相互作用。此外，它还与 ITGAL 相互作用（通过 I 域）。
种属

Rat
表达系统

HEK293
标签

C-hFc
蛋白编号

Q9JHY1 (K27-G238)
基因 ID
蛋白结构
N-term
JAM-A (K27-G238)
Accession # Q9JHY1
hFc
C-term
同用名
Junctional Adhesion Molecule A; JAM-A; JAM-1; PAM-1; CD321; F11R; JCAM
分子量

Approximately 60 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

JAM-A/CD321 Protein, Rat (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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