LAMP3/CD208 蛋白, Rhesus Macaque (HEK293, His)

The LAMP3/CD208 protein is a lysosomal membrane glycoprotein that actively participates in the unfolded protein response (UPR), aiding protein degradation and cell survival during proteasome dysfunction. It is essential for lysosome-autophagosome fusion, where it regulates the autophagy process. LAMP3/CD208 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived LAMP3/CD208 protein, expressed by HEK293 , with C-His labeled tag. The total length of LAMP3/CD208 Protein, Rhesus Macaque (HEK293, His) is 354 a.a., with molecular weight of ~60-95 KDa.

LAMP3/CD208 蛋白是一种溶酶体膜糖蛋白，积极参与未折叠蛋白反应 (UPR)，有助于蛋白酶体功能障碍条件下的蛋白降解和细胞存活。此外，它在促进溶酶体与自噬体融合从而调节自噬过程中发挥着至关重要的作用。除了在细胞稳态中的作用之外，LAMP3/CD208 还通过激活 PI3K/Akt 通路来促进肝细胞脂肪生成。此外，有证据表明它参与树突状细胞功能和适应性免疫。在结构上，LAMP3/CD208 作为单体并与 FURIN 相互作用以执行其多种细胞功能。

Measured by its ability to enhance MDA-MB-231 cells migration. The ED₅₀ for this effect is 0.397 μg/mL, corresponding to a specific activity is 2.516×10³ U/mg.

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  Measured by its ability to enhance MDA-MB-231 cells migration. The ED₅₀ for this effect is 0.397 μg/mL, corresponding to a specific activity is 2.516×10³ U/mg.

Rhesus Macaque

HEK293

C-6*His

Q8MJJ2 (K28-T381)

574213  [NCBI]

KAFPKTRDYSQPTAAATGQDIAKPVQQPANQAPHQTLAARLMDGHITFQTAATIKTPTTTPVTTKNTPTTSPIIYTLVTTQATSNNSHTAPPLTKVTVGPSLAPYSLPPTITPPAHTTGTSSSTVNHTTGNATQPSNQTTLPATLSIAPHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGSTLAPQPSSIKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNLDPNATQASGNCGTRNSNLLLNFQGGFVNLTFTKDEGSYYISEVGACLTVSDPETIYQGMKHAVVMFQTVVGHSFKCVSEQSLQLSAHLQLKTTNVQLQAFDFEDDHFGNVDECSSDYT

Approximately 60-95 kDa due to the glycosylation

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, PH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.