LOX-1/OLR1 蛋白, Mouse (HEK293, His)

The LOX-1/OLR1 protein is a receptor on vascular endothelial cells that promotes the recognition, internalization, and degradation of oxidatively modified low-density lipoprotein (oxLDL). This process is indicative of atherosclerosis and triggers endothelial cell activation, pro-inflammatory responses, oxidative conditions, and apoptosis. LOX-1/OLR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LOX-1/OLR1 protein, expressed by HEK293 , with N-His labeled tag. The total length of LOX-1/OLR1 Protein, Mouse (HEK293, His) is 304 a.a., with molecular weight of 55-63 kDa.

LOX-1/OLR1 是血管内皮细胞识别、内化和降解氧化修饰低密度脂蛋白 (oxLDL) 的关键受体。oxLDL 与 LOX-1 的结合触发血管内皮细胞激活和功能障碍，导致促炎症反应、氧化条件增加和细胞凋亡。这种相互作用诱导 NF-κ-B 的激活，促进细胞内活性氧的产生并促进各种促动脉粥样硬化的细胞反应，包括减少一氧化氮释放、单核细胞粘附和细胞凋亡。除了在动脉粥样硬化中的作用之外，LOX-1 还充当 HSP70 的受体，参与抗原交叉呈递给树突状细胞中的初始 T 细胞。此外，在内毒素诱导的炎症过程中，它在内毒素诱导的炎症过程中作为血管界面上的白细胞粘附分子发挥作用，从而在炎症过程中发挥关键作用。此外，LOX-1 还可作为晚期糖基化终末产物、活化血小板、单核细胞、凋亡细胞以及革兰氏阴性和革兰氏阳性细菌的受体。该受体以同二聚体形式存在，可能形成由三个同二聚体组成的六聚体，并与 HSP70 相互作用。

Mouse

HEK293

N-His

Q9EQ09 (R60-I363)

108078  [NCBI]

55-63 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.