MESDC2 蛋白, Human (HEK293, His)

The MESDC2 protein acts as a chaperone and plays a specific role in promoting the folding of the β-propeller/EGF module within the low-density lipoprotein receptor (LDLR) family.In addition to participating in LDLR folding, MESDC2 acts as an important regulator of the Wnt pathway by chaperoning the coreceptors LRP5 and LRP6 to the plasma membrane, thereby affecting Wnt signaling.MESDC2 Protein, Human (HEK293, His) is the recombinant human-derived MESDC2 protein, expressed by HEK293 , with C-His labeled tag.

MESDC2 蛋白作为伴侣，在促进低密度脂蛋白受体 (LDLR) 家族内 β-螺旋桨/EGF 模块的折叠方面发挥特定作用。除了参与 LDLR 折叠之外，MESDC2 还通过将辅助受体 LRP5 和 LRP6 陪伴至质膜，从而影响 Wnt 信号转导，从而充当 Wnt 通路的重要调节剂 (PubMed:17488095)。在胚胎发育中，MESDC2 在指定极性和诱导中胚层形成方面发挥着重要作用。此外，它还通过促进 LRP4 的细胞表面表达（通过相似性）对神经肌肉接头 (NMJ) 的形成做出重大贡献。该蛋白还可以调节凋亡的视网膜色素上皮 (RPE) 细胞的吞噬作用（通过相似性）。作为单体，MESDC2 与 LRP5 和 LRP6 相互作用，防止它们聚集并引导它们到达质膜。此外，MESDC2 与 LRP4 相互作用，促进 LRP4 的糖基化和细胞表面表达（通过相似性）。

Human

HEK293

C-6*His

Q14696-1 (A34-K230)

23184  [NCBI]

AEGSPGTPDESTPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEENRAGNK

Approximately 27 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.