MTSS1 蛋白, Human (His)

MTSS1 Protein is a protein down-regulated in MTSS1 in metastatic bladder carcinoma cell lines. MTSS1 is widely expressed but most abundant in spleen, thymus, testis, prostate and peripheral blood, with low levels also detected in uterus and colon. MTSS1 is proposed to function as a metastatic suppressor protein in both bladder and prostate cancers. MTSS1 Protein, Human (His) is the recombinant human-derived MTSS1 protein, expressed by E. coli , with N-His labeled tag. The total length of MTSS1 Protein, Human (His) is 250 a.a., with molecular weight of ~28 kDa.

MTSS1 蛋白是转移性膀胱癌细胞株中MTSS1 表达下调的蛋白。MTSS1 广泛表达于脾脏、胸腺、睾丸、前列腺和外周血中，子宫和结肠中也有少量表达。MTSS1 被认为在膀胱癌和前列腺癌中发挥转移抑制蛋白的作用。MTSS1 具有肌动蛋白单体结合活性、同源蛋白结合活性和信号受体结合活性。MTSS1 参与细胞对流体剪切力的反应、上皮细胞增殖和泌尿生殖系统发育的负调控。MTSS1 作用于肌动蛋白微丝聚合、黏附连接维持和镁离子稳态等过程的上游或内部。MTSS1 定位于肌动蛋白细胞骨架^[1]。

Human

E. coli

N-6*His

EAW92073 (M1-S250)

9788  [NCBI]

MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGS

Approximately 28 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.