MYDGF 蛋白, Human (His)

The MYDGF protein is derived from bone marrow mononuclear cells and significantly promotes cardioprotection and post-myocardial infarction (MI) repair. Its functions include promoting cardiomyocyte survival and promoting adaptive angiogenesis. MYDGF Protein, Human (His) is the recombinant human-derived MYDGF protein, expressed by E. coli , with N-6*His labeled tag.

MYDGF 蛋白是一种源自骨髓单核细胞的旁分泌蛋白，在心肌梗塞 (MI) 后的心脏保护和修复中发挥着至关重要的作用。其多方面的功能包括促进心肌细胞存活和促进适应性血管生成。MYDGF 通过涉及 MAPK1/3、STAT3 和 CCND1 的信号通路刺激内皮细胞增殖。此外，它还通过 PI3K/AKT 依赖性信号通路抑制心肌细胞凋亡。该蛋白参与内皮细胞增殖和血管生成，强调了它在介导对心脏恢复和组织修复至关重要的过程中的重要性，使其成为心血管疾病的潜在治疗靶点。

Measured by its binding ability in a functional ELISA. Immobilized Human MYDGF at 2 μg/mL (100 μL/well) can bind Human P4HB (HY-P71087). The ED₅₀ for this effect is 2.151-3.397 μg/mL.

Human

E. coli

N-6*His

Q969H8 (S33-L173)

56005  [NCBI]

SEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL

Approximately 17.0-18 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 4 mM HCl or PBS, pH 7.4, 10% trehalose, 0.02% Tween80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.