N-Cadherin 蛋白, Mouse (HEK293)

N-Cadherin Protein is a calcium-dependent cell adhesion protein that mediates homotypic cell-cell adhesion by dimerizing with a CDH2 chain from another cell. N-Cadherin Protein plays a role in cell adhesion, cell sorting, and neural development. N-Cadherin Protein, Mouse (HEK293) is the recombinant mouse-derived N-Cadherin protein, expressed by HEK293 , with tag free. The total length of N-Cadherin Protein, Mouse (HEK293) is 699 a.a., with molecular weight of ~91 & 114 kDa, respectively.

N-钙粘蛋白是一种钙依赖性细胞粘附蛋白，主要通过与邻近细胞的 CDH2 链二聚化来促进同型细胞间粘附。该特性有助于异质细胞类型的分选。此外，N-钙粘蛋白通过将神经干细胞锚定到成体室管膜下区的室管膜细胞上，充当神经干细胞静止的调节剂。MMP24 介导的 N-钙粘蛋白裂解会影响这种锚定，从而调节神经干细胞的静止状态。在胰腺β细胞中，N-钙粘蛋白在与神经嵴干细胞形成细胞间连接方面发挥着至关重要的作用，促进后者过程的延伸。该蛋白质对于适当的神经突分支、突触前和突触后组织至关重要，并且可能参与神经元识别机制。在海马神经元中，N-钙粘蛋白可能调节树突棘密度。在功能上，N-钙粘蛋白通过其胞外区域形成同二聚体，并且还可以与其他钙粘蛋白反式形成异二聚体，涉及来自另一个细胞的钙粘蛋白链。与 CDCP1、PCDH8 和 OBSCN 的相互作用进一步强调了 N-钙粘蛋白细胞活性的复杂性，并可能通过 TAOK2/p38 MAPK 途径内化。此外，它在包含 FGFR4、NCAM1、CDH2、PLCG1、FRS2、SRC、SHC1、GAP43 和 CTTN 的复合物中被鉴定，突出了它与多种细胞成分的关联。

Mouse

HEK293

Tag Free

P15116 (S26-A724)

12558  [NCBI]

Approximately 91&114 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.