Ninjurin-1 蛋白, Rat (HEK293, Fc)

The Ninjurin-1 protein is a key player in programmed cell death, driving plasma membrane rupture in the necroptosis and pyroptosis pathways.Ninjurin-1 oligomerizes downstream of gasdermin or MLKL activation, inducing cell lysis and releasing inflammatory DAMPs.Ninjurin-1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Ninjurin-1 protein, expressed by HEK293 , with N-hFc labeled tag.

Ninjurin-1 蛋白是程序性细胞死亡中的关键效应子，在坏死性凋亡和焦亡途径中协调质膜破裂。在 Gasdermin 或 MLKL 激活的下游，Ninjurin-1 寡聚化，将亲水面引入膜中并诱导细胞溶解，释放损伤相关分子模式 (DAMP)，从而促进炎症反应。此外，它还通过直接结合 LPS 来调节全身炎症期间由脂多糖触发的 Toll 样受体 4 信号传导。在炎症中，Ninjurin-1 促进白细胞迁移和巨噬细胞跨内皮迁移，促进单核细胞募集到炎症部位并减轻动脉粥样硬化。除了在炎症中发挥作用外，Ninjurin-1 还充当亲同性跨膜粘附分子，有助于轴突生长、血管生成和破骨细胞发育等过程。其分泌形式具有趋化活性，可增强单核细胞的募集并在动脉粥样硬化中充当抗炎介质。

Rat

HEK293

N-hFc

P70617 (M1-P79)

25338  [NCBI]

MDPGTEEYELNGDLRPGSPGSPDASPPRWGLRNRPINVNHYANKKSAAESMLDIALLMANASQLKAVVEQGNEFAFFVP

Approximately 50 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS, pH 7.4 . For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.