NKp30/NCR3 蛋白, Human (120a.a, HEK293, His)

NKp30/NCR3 protein is a cell membrane receptor on NK cells and is activated by binding to ligands such as BAG6 and NCR3LG1. This activation enhances NK cell cytotoxicity against neighboring cells that produce these ligands, including tumor cells. NKp30/NCR3 Protein, Human (120a.a, HEK293, His) is the recombinant human-derived NKp30/NCR3 protein, expressed by HEK293 , with C-6*His labeled tag.

NKp30/NCR3 蛋白作为自然杀伤 (NK) 细胞的细胞膜受体，在与 BAG6 和 NCR3LG1 等细胞外配体结合后被激活。这种激活刺激 NK 细胞针对产生这些配体的邻近细胞的细胞毒性，从而控制 NK 细胞针对各种靶标（包括肿瘤细胞）的细胞毒性。BAG6 与 NCR3 的结合不仅增强了 NK 细胞介导的对未获得成熟表型的骨髓树突状细胞 (DC) 的杀伤作用，而且还诱导 NK 细胞释放 TNFA 和 IFNG。这反过来又促进骨髓树突状细胞的成熟。在未配体形式下，NKp30/NCR3 以同二聚体形式存在，并与 CD3Z、NCR3LG1 和 BAG6 相互作用，突出了其在免疫反应和 NK 细胞介导的细胞毒性中作为多方面调节剂的作用。

Human

HEK293

C-6*His

O14931-1 (L19-T138)

259197  [NCBI]

LWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFLHDHQAELHIRDVRGHDASIYVCRVEVLGLGVGTGNGTRLVVEKEHPQLGAGT

20-31 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.