2. Gene
  3. NCR3 - natural cytotoxicity triggering receptor 3 Gene

NCR3 - natural cytotoxicity triggering receptor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天然细胞毒性触发受体 3

种属: Homo sapiens

同用名: 1C7; MALS; CD337; LY117; NKp30

基因 ID: 259197 | 基因类型: protein coding

关于 NCR3

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,588,895-31,593,006 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 590 orthologues, 14 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 5.8), spleen (RPKM 4.7) and 18 other tissues.

功能概要

该基因编码的蛋白质是一种天然细胞毒性受体 (NCR) ，可帮助 NK 细胞裂解肿瘤细胞。编码的蛋白质与 T 细胞受体 CD3-zeta (CD247) 相互作用。该基因 5' 非翻译区的单核苷酸多态性与轻度疟疾易感性有关。已发现该基因编码不同亚型的三种转录变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

NCR3 基因产物(3)

mRNA Protein Name
NM_001145466.2 NP_001138938.1 natural cytotoxicity triggering receptor 3 isoform b precursor
NM_001145467.2 NP_001138939.1 natural cytotoxicity triggering receptor 3 isoform c precursor
NM_147130.3 NP_667341.1 natural cytotoxicity triggering receptor 3 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21444796 GOA
enables immune receptor activity IDA
IDA: 通过直接分析推断
15294952 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18055229 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NK T cell activation IDA
IDA: 通过直接分析推断
15294952 GOA
involved in immune response-activating cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
18852879 GOA
involved in natural killer cell activation IDA
IDA: 通过直接分析推断
18852879 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
16304049 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
15294952 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCR3 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (19 - 127)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

natural cytotoxicity triggering receptor 3

NK-p30

重组 NCR3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72506 NKp30/NCR3 Protein, Human (120a.a, HEK293, His) O14931-1 (L19-T138) ≥95%
HY-P77811 NKp30/NCR3 Protein, Human (120a.a, HEK293, Fc) O14931-1 (L19-T138) ≥95%
HY-P77812 NKp30/NCR3 Protein, Human (HEK293, His-Avi) O14931-1 (L19-T138) ≥95%
HY-P77813 NKp30/NCR3 Protein, Human (Biotinylated, HEK293, His-Avi) O14931-1 (L19-T138) ≥95%

关联疾病

疾病名称 别名
Malaria, Mild

Malaria, Mild, Susceptibility To

Mals

Mal

Xx Males

Karyotype 47,Xyy

Double Y Syndrome

Xyy Syndrome
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Nk Cell Deficiency
Bronchiectasis 1
Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09100 NCR3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09101 NCR3LG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NCR3 VGNC VGNC:74990
Canis familiaris NCR3 VGNC VGNC:43666
Mus musculus NCR3 MGD MGI:2149332
Bos taurus NCR3 VGNC VGNC:31927
Rattus norvegicus NCR3 RGD RGD:727881
Macaca fascicularis NCR3 NCBI NCBI:102133932
Others NCR3 NCBI
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