p67phox 蛋白, Human (sf9, His-GST)

p67phox is central to the activation of NADPH oxidase, which is critical for superoxide production. p67phox forms heterodimers with CYBA and CYBB and interacts with NCF4 and NCF1 to establish important connections within the complex. p67phox Protein, Human (sf9, His-GST) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of p67phox Protein, Human (sf9, His-GST) is 526 a.a., with molecular weight of 80-90 kDa.

p67phox 蛋白在潜在 NADPH 氧化酶的激活中发挥着关键作用，这是超氧化物产生所必需的过程。作为 NADPH 氧化酶复合物的关键成分，它与膜蛋白 CYBA 和 CYBB 以及胞质亚基 NCF1、NCF2 和 NCF4 形成异二聚体。值得注意的是，p67phox 与 NCF4 和 NCF1 相互作用，通过其 C 端 SH3 结构域在复合物内建立关键连接。此外，它与 SYTL1 和 RAC1 结合，并可能与 NOXO1 相互作用，突出了其与监管元件相关的多功能性。与 S100A8、钙卫蛋白 (S100A8/9) 和 GBP7 的进一步相互作用强调了参与 NADPH 氧化酶活性调节的复杂网络。GBP7 的存在增强了与 CYBB 的相互作用，强调了这些蛋白质-蛋白质关联在协调超氧化物生成中的动态性质。

Human

Sf9 insect cells

N-His;N-GST

P19878 (M1-V526)

4688  [NCBI]

80-90 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM Nacl, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.