Plasma kallikrein/KLKB1 蛋白, Mouse (HEK293, His)

Plasma kallikrein/KLKB1 enzymatically cleaves Lys-Arg and Arg-Ser bonds, triggering factor XII activation upon binding to a negatively charged surface.It liberates bradykinin from HMW kininogen and is implicated in the renin-angiotensin system, potentially converting prorenin into renin.This underscores the diverse and essential functions of Plasma kallikrein/KLKB1 in various physiological processes.Plasma kallikrein/KLKB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag.

血浆激肽释放酶/KLKB1 蛋白通过选择性裂解 Lys-Arg 和 Arg-Ser 键表现出酶活性。与带负电的表面结合后，它会启动因子 XII 的相互激活。此外，该蛋白在从 HMW 激肽原中释放缓激肽方面发挥着至关重要的作用。有趣的是，它与肾素-血管紧张素系统有关，可能有助于肾素原转化为肾素。这种复杂的相互作用强调了血浆激肽释放酶/KLKB1 蛋白在各种生理过程中的多样化和基本功能。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

C-His

P26262 (G20-A638)

16621  [NCBI]

75-85 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 20 mM NaAc, 150 mM NaCl, pH 5.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.