PPC-DC 蛋白, Human (His, solution)

PPC-DC proteins are central players in cellular ubiquitination, covalently linking ubiquitin to target proteins. Its critical role extends to the selective degradation of misfolded membrane proteins, an important process in endoplasmic reticulum-associated degradation (ERAD). PPC-DC Protein, Human (His, solution) is the recombinant human-derived PPC-DC protein, expressed by E. coli , with N-6*His labeled tag.

UBE2J2 蛋白在细胞泛素化过程中发挥关键作用，促进泛素与靶蛋白的共价连接。其功能意义延伸到错误折叠膜蛋白的选择性降解，这是内质网相关降解（ERAD）的一个重要方面。这种参与强调了UBE2J2通过积极参与内质网内蛋白质折叠的质量控制来维持细胞稳态的作用。此外，UBE2J2 与 GATOR2 复合物合作，催化 NPRL2 的“Lys-6”连接泛素化，进一步强调其对特定细胞途径的调节影响，特别是与蛋白质质量控制相关的途径。

Human

E. coli

N-6*His

Q96CD2-1 (M1-S204)

60490  [NCBI]

MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS

Approximately 27 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 1 mM DTT, 10% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.