2. Gene
  3. PPCDC - phosphopantothenoylcysteine decarboxylase Gene

PPCDC - phosphopantothenoylcysteine decarboxylase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸泛酰半胱氨酸脱羧酶

种属: Homo sapiens

同用名: coaC; MDS018; PPC-DC

基因 ID: 60490 | 基因类型: protein coding

关于 PPCDC

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,023,590-75,050,726 (from NCBI)

This gene has 11 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 1.6), appendix (RPKM 1.5) and 25 other tissues.

功能概要

从泛酸 (维生素 B5) 生物合成辅酶 A (CoA) 是原核生物和真核生物中必不可少的通用途径。 PPCDC (EC 4.1.1.36) ，该途径中的最后一种酶，将磷酸泛酰半胱氨酸转化为 4-主要磷酸泛硫因 (Daugherty 等人，2002 [PubMed 11923312]) 。[OMIM 提供，2008 年 3 月]

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last Enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

PPCDC 基因产物(6)

mRNA Protein Name
NM_001301101.2 NP_001288030.1 phosphopantothenoylcysteine decarboxylase isoform b
NM_001301102.2 NP_001288031.1 phosphopantothenoylcysteine decarboxylase isoform c
NM_001301103.2 NP_001288032.1 phosphopantothenoylcysteine decarboxylase isoform d
NM_001301104.2 NP_001288033.1 phosphopantothenoylcysteine decarboxylase isoform e
NM_001301105.2 NP_001288034.1 phosphopantothenoylcysteine decarboxylase isoform e
NM_021823.5 NP_068595.3 phosphopantothenoylcysteine decarboxylase isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FMN binding IDA
IDA: 通过直接分析推断
14501115 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
14501115 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables phosphopantothenoylcysteine decarboxylase activity EXP
EXP: 通过实验结果推断
15581364 GOA
enables phosphopantothenoylcysteine decarboxylase activity IDA
IDA: 通过直接分析推断
11923312 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in coenzyme A biosynthetic process IDA
IDA: 通过直接分析推断
11923312 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPCDC 蛋白结构

Flavoprotein

Flavoprotein: Flavoprotein (19 - 149)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

phosphopantothenoylcysteine decarboxylase

PPCDC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPCDC Q96CD2 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
种属内
PPCDC Q96CD2 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
种属内
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Array
32296183
种属内
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Prey Pooling
25416956
种属内
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Prey Pooling
32296183
种属内
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Y2H Array
31515488
种属内
PPCDC Q96CD2 FOXR1 Homo sapiens Q6PIV2
Validated Y2H
25416956
种属内
PPCDC Q96CD2 TGM7 Homo sapiens Q96PF1
Validated Y2H
32296183
种属内
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
种属内
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Validated Y2H
25416956
种属内
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
种属内
PPCDC Q96CD2 TXN2 Homo sapiens Q99757
Y2H Array
25416956
种属内
PPCDC Q96CD2 PPIG Homo sapiens Q13427
Y2H Prey Pooling
25416956
种属内
PPCDC Q96CD2 PPIG Homo sapiens Q13427
Y2H Array
25416956
种属内
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Y2H Prey Pooling
32296183
种属内
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Validated Y2H
32296183
种属内
PPCDC Q96CD2 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Y2H Array
25416956
种属内
PPCDC Q96CD2 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
种属内
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
GMS
26514574
种属内
PPCDC Q96CD2 PPCDC Homo sapiens Q96CD2
Y2H Array
32296183
种属内
PPCDC Q96CD2 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
种属内
PPCDC Q96CD2 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
种属内
PPCDC Q96CD2 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
种属内
PPCDC Q96CD2 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属内
PPCDC Q96CD2 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
25416956
种属内
PPCDC Q96CD2 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32296183
种属内
PPCDC Q96CD2 ZNF232 Homo sapiens Q9UNY5
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PPCDC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71222 PPC-DC Protein, Human (His) Q96CD2-1 (M1-S204) ≥95%
HY-P71222A PPC-DC Protein, Human (His, solution) Q96CD2-1 (M1-S204) ≥95%

关联疾病

疾病名称 别名
Cecum Carcinoma

Cecum Cancer

Caecum Carcinoma

Carcinoma Of Cecum

Cecal Cancer

Malignant Neoplasm Of Caecum

Malignant Tumor Of The Cecum
Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum
Thyroid Dyshormonogenesis 6

TDH6

Genetic Defect In Thyroid Hormonogenesis 6

Thyroid Hormonogenesis, Genetic Defect In, 6

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 6

Chdh6

Congenital Hypothyroidism Due To Dyshormonogenesis Type 6
Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon
Neurodegeneration With Brain Iron Accumulation 1

Pantothenate Kinase-Associated Neurodegeneration

Pkan

NBIA1

Hallervorden-Spatz Disease

Hallervorden-Spatz Syndrome

Pigmentary Pallidal Degeneration

Neuroaxonal Dystrophy, Late Infantile

Neurodegeneration With Brain Iron Accumulation Type 1

Classic Pantothenate Kinase-Associated Neurodegeneration

Pkan Neuroaxonal Dystrophy, Juvenile-Onset

Brain Iron Accumulation Type I Syndrome

Nbia

Neurodegeneration With Brain Iron Accumulation

Nbia1, Classic Form

Neurodegeneration With Brain Iron Accumulation Type 1, Classic Form

Pkan, Classic Form

Atypical Pantothenate Kinase-Associated Neurodegeneration

Nbia1, Atypical Form

Neurodegeneration With Brain Iron Accumulation Type 1, Atypical Form

Pkan, Atypical Form

Hss

Pkan Neuroaxonal Dystrophy Juvenile-Onset

Neurodegeneration, With Brain Iron Accumulation, Type 1
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10934 PPCDC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PPCDC VGNC VGNC:64306
Rattus norvegicus PPCDC RGD RGD:1306267
Mus musculus PPCDC MGD MGI:1914062
Bos taurus PPCDC VGNC VGNC:33188
Macaca mulatta PPCDC VGNC VGNC:76124
Canis familiaris PPCDC VGNC VGNC:44840
Others PPCDC NCBI
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